Effect of HIFU on endometrial receptivity and sex hormone level in uterine fibroid patients and analysis of influencing factors for its treatment rate
| Autor: | Dexing Su, Bingcheng Guo, Yanyan Dong, Cuihong Xing, Yongmei Cui, Xiaohui Gao |
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| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
medicine.medical_specialty endometrial receptivity Uterine fibroids medicine.medical_treatment Urology influencing factor Luteal phase treatment rate Follicle-stimulating hormone Sex hormone-binding globulin Immunology and Microbiology (miscellaneous) Medicine sex hormone level biology Clinical pathology business.industry Ultrasound Articles uterine fibroid General Medicine medicine.disease Ablation High-intensity focused ultrasound high intensity focused ultrasound biology.protein business |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Effect of high intensity focused ultrasound (HIFU) uterine fibroid ablation on the endometrial receptivity and sex hormone level in uterine fibroid patients and the influencing factors for treatment rate were investigated. A retrospective analysis of 266 uterine fibroid patients admitted to the Department of Gynaecology in the Jining Maternity and Child Care Hospital from October 2013 to October 2016 was performed. Among them, observation group was treated with HIFU ablation (n=143), control group with myomectomy (n=123). The pulsatility index (PI) and the resistance index (RI) of the uterine arterial blood flow were measured during the luteal phase of menstruation by transvaginal ultrasonography. The serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol (E2) were detected by chemical immunofluorescence. The relationship between HIFU treatment rate and clinical pathology of uterine fibroid patients was analyzed, and univariate/multivariate regression analysis was used to analyze the influencing factors for HIFU treatment rate. There was no significant difference in preoperative and postoperative PI and RI between the two groups (P>0.05); no significant difference between preoperative and postoperative PI/RI in the same group (P>0.05). There was no significant difference in preoperative and postoperative LH, FSH and E2 between the two groups (P>0.05); no significant difference between preoperative LH and postoperative LH in the same group (P>0.05), neither FSH or E2 (P>0.05). Results of multivariate analysis showed that fibroid location and ultrasound contrast intensity were independent influencing factors for HIFU treatment rate (P |
| Databáze: | OpenAIRE |
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