α-Arylation of Ketones Using Highly Active, Air-Stable (DtBPF)PdX2 (X = Cl, Br) Catalysts

Autor:	Thomas J. Colacot, Gabriela Alexandra Grasa
Rok vydání:	2007
Předmět:	Denticity Chemistry Ligand Aryl Organic Chemistry Bite angle Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound Propiophenone Catalytic cycle Yield (chemistry) Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 9:5489-5492
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol702430a
Popis:	alpha-Arylation of various ketones with aryl chlorides and bromides using the well-defined and air-stable (DtBPF)PdX2 (X = Cl, Br) catalysts gave 80-100% yield of the coupled products under relatively mild conditions at low catalyst loadings. The X-ray structure of (DtBPF)PdCl2 revealed the largest P-Pd-P bite angle (104.2 degrees ) for a ferrocenyl bisphosphine ligand. 31P NMR monitoring of (DtBPF)PdCl2-catalyzed reaction of 4-chlorotoluene with propiophenone indicated that DtBPF remained coordinated in a bidentate mode during the catalytic cycle.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0068000870225c6b42280ae47c70e7 https://doi.org/10.1021/ol702430a Zobrazit plný text záznamu