Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer

Autor: Michael O. Woods, Marc J. Gunter, Andrew T. Chan, Richard B. Hayes, Yi Lin, Steven Gallinger, Robert S. Sandler, D. Timothy Bishop, Martha L. Slattery, Peter S. Liang, Mengmeng Du, Temitope O. Keku, Mark A. Jenkins, Stephen B. Gruber, Gad Rennert, Tabitha A. Harrison, Alexi N. Archambault, Michael Hoffmeister, Ulrike Peters, Mingyang Song, Neil Murphy, Rish K. Pai, Graham Casey, Li Hsu, Peter T. Campbell, Aung Ko Win, Hermann Brenner, Jihyoun Jeon, Patrick S. Parfrey, Lori C. Sakoda, Victor Moreno, Loic Le Marchand, Li Li, Yu-Ru Su, Jenny Chang-Claude, Anne Zeleniuch-Jacquotte, Jane C. Figueiredo, Polly A. Newcomb
Rok vydání: 2021
Předmět:
Dietary Fiber
Cancer Research
Colorectal cancer
0302 clinical medicine
Risk Factors
Epidemiology
Odds Ratio
Age of Onset
Early Detection of Cancer
education.field_of_study
Factors de risc en les malalties
Incidence
Incidence (epidemiology)
Anti-Inflammatory Agents
Non-Steroidal
Middle Aged
Alcoholism
Oncology
Occult Blood
030220 oncology & carcinogenesis
Colonic Neoplasms
Red meat
Educational Status
030211 gastroenterology & hepatology
Colorectal Neoplasms
AcademicSubjects/MED00010
Adult
medicine.medical_specialty
Meat
Risk factors in diseases
Population
Article
Drug/alcohol abstinence
03 medical and health sciences
Càncer colorectal
Internal medicine
Confidence Intervals
medicine
Animals
Humans
education
Aged
Rectal Neoplasms
business.industry
Ecological study
Odds ratio
medicine.disease
Logistic Models
Solicited Editorial
Case-Control Studies
Cattle
business
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
JNCI Cancer Spectrum
ISSN: 2515-5091
Popis: Background Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by anatomic subsite. Methods Using data pooled from 13 population-based studies, we studied 3767 CRC cases and 4049 controls aged younger than 50 years and 23 437 CRC cases and 35 311 controls aged 50 years and older. Using multivariable and multinomial logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between risk factors and early-onset CRC and by anatomic subsite. Results Early-onset CRC was associated with not regularly using nonsteroidal anti-inflammatory drugs (OR = 1.43, 95% CI = 1.21 to 1.68), greater red meat intake (OR = 1.10, 95% CI = 1.04 to 1.16), lower educational attainment (OR = 1.10, 95% CI = 1.04 to 1.16), alcohol abstinence (OR = 1.23, 95% CI = 1.08 to 1.39), and heavier alcohol use (OR = 1.25, 95% CI = 1.04 to 1.50). No factors exhibited a greater excess in early-onset compared with late-onset CRC. Evaluating risks by anatomic subsite, we found that lower total fiber intake was linked more strongly to rectal (OR = 1.30, 95% CI = 1.14 to 1.48) than colon cancer (OR = 1.14, 95% CI = 1.02 to 1.27; P = .04). Conclusion In this large study, we identified several nongenetic risk factors associated with early-onset CRC, providing a basis for targeted identification of those most at risk, which is imperative in mitigating the rising burden of this disease.
Databáze: OpenAIRE
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