GDF-15, a mitochondrial disease biomarker, is associated with the severity of multiple sclerosis
| Autor: | Zenshi Miyake, Naomi Mamada, Tetsuya Moriyama, Shuichi Yatsuga, Kumi Yanagiha, Satoshi Aizawa, Akiko Ishii, Kazuhiro Ishii, Masahiko Watanabe, Akira Tamaoka, Seitaro Nohara, Takashi Hosaka, Makoto Terada, Kiyotaka Nakamagoe, Yasutoshi Koga, Hiroshi Tsuji, Naoki Tozaka, Fumiko Yamamoto, Yasushi Tomidokoro, Tetsuto Yamaguchi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Growth Differentiation Factor 15 Mitochondrial Diseases Multiple Sclerosis Mitochondrial disease 03 medical and health sciences Disability Evaluation Young Adult 0302 clinical medicine Internal medicine Limbic Encephalitis medicine Humans 030212 general & internal medicine Amyotrophic lateral sclerosis Aged Aged 80 and over Expanded Disability Status Scale business.industry Multiple sclerosis Limbic encephalitis Confounding Amyotrophic Lateral Sclerosis Neuromyelitis Optica Age Factors Transforming growth factor beta superfamily Middle Aged medicine.disease Fibroblast Growth Factors Neurology embryonic structures Biomarker (medicine) Female Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of the neurological sciences. 405 |
| ISSN: | 1878-5883 |
| Popis: | GDF-15, a member of the transforming growth factor beta superfamily, regulates inflammatory and apoptotic pathways in various diseases, such as heart failure, kidney dysfunction, and cancer. We aimed to clarify potentially confounding variables affecting GDF-15 and demonstrate its utility as a mitochondrial biomarker using serum samples from 15 patients with mitochondrial diseases (MD), 15 patients with limbic encephalitis (LE), 10 patients with multiple sclerosis/neuromyelitis optica spectrum disorders (MS/NMOSD), and 19 patients with amyotrophic lateral sclerosis (ALS). GDF-15 and FGF-21 were significantly elevated in MD. GDF-15 and FGF-21 showed a good correlation in MD but not in LE, MS, and ALS. GDF-15 was potentially influenced by age in LE, MS/NMOSD, and ALS but not in MD. FGF-21 was not correlated with age in MS/NMOSD, ALS, LE, and MD. GDF-15 was not correlated with clinical features in LE or BMI or body weight in ALS. GDF-15 positively correlated with the Expanded Disability Status Scale (EDSS) in MS/NMOSD, while EDSS showed no correlation with age. In conclusion, the results revealed that GDF-15 may be influenced by EDSS in MS/NMOPSD and by age in LE, MS/NMOSD, and ALS but not in MD. Mitochondrial damage in MS/NMOSD is a potentially confounding variable affecting GDF-15. |
| Databáze: | OpenAIRE |
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