Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers
| Autor: | Antonios G. Kanaras, Davide Giust, Afaf H. El-Sagheer, Otto L. Muskens, Tom Brown, Peter M. Lackie, Maria Eleni Kyriazi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cell Survival
Metal Nanoparticles General Physics and Astronomy Nanoparticle Antineoplastic Agents Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Drug Delivery Systems Cell Line Tumor Sense (molecular biology) medicine Humans General Materials Science Doxorubicin RNA Messenger Copper-free click chemistry Cell Proliferation Mitoxantrone Chemistry General Engineering 021001 nanoscience & nanotechnology 0104 chemical sciences Targeted drug delivery Colloidal gold Drug delivery Gold Drug Screening Assays Antitumor 0210 nano-technology Dimerization medicine.drug |
| Zdroj: | ACS Nano. 12:3333-3340 |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | The design of nanoparticulate systems which can perform multiple synergistic functions in cells with high specificity and selectivity is of great importance in applications. Here we combine recent advances in DNA-gold nanoparticle self-assembly and sensing to develop gold nanoparticle dimers that are able to perform multiplexed synergistic functions within a cellular environment. These dimers can sense two mRNA targets and simultaneously or independently deliver one or two DNA-intercalating anticancer drugs (doxorubicin and mitoxantrone) in live cells. Our study focuses on the design of sophisticated nanoparticle assemblies with multiple and synergistic functions that have the potential to advance sensing and drug delivery in cells. |
| Databáze: | OpenAIRE |
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