A Randomized, Controlled Investigation of Motor Cortex Transcranial Magnetic Stimulation (TMS) Effects on Quantitative Sensory Measures in Healthy Adults
| Autor: | Will Beam, Alok Madan, Mark S. George, Jeffrey J. Borckardt, Richard H. Gracely, Sophie Katz, Arthur R. Smith, David R. Patterson, Mark P. Jensen, Scott T. Reeves |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Pain Threshold medicine.medical_specialty Hot Temperature medicine.medical_treatment Pain Stimulation Sensory system Audiology Article Young Adult Sensory threshold medicine Humans Pain Management Single-Blind Method Thermosensing Pain Measurement Cross-Over Studies business.industry Motor Cortex Chronic pain medicine.disease Transcranial Magnetic Stimulation Cold Temperature Transcranial magnetic stimulation Anesthesiology and Pain Medicine medicine.anatomical_structure Brain stimulation Neuropathic pain Female Neurology (clinical) Analgesia business Motor cortex |
| Zdroj: | The Clinical Journal of Pain. 27:486-494 |
| ISSN: | 0749-8047 |
| DOI: | 10.1097/ajp.0b013e31820d2733 |
| Popis: | OBJECTIVES There is emerging evidence that transcranial magnetic stimulation (TMS) can produce analgesic effects in clinical samples and in healthy adults undergoing experimentally induced pain; and the field of minimally invasive brain stimulation for the management of pain is expanding rapidly. Although motor cortex is the most widely used cortical target for TMS in the management of neuropathic pain, few studies have systematically investigated the analgesic effects of a full range of device parameters to provide initial hints about what stimulation intensities and frequencies are most helpful (or even potentially harmful) to patients. Further, there is considerable inconsistency between studies with respect to laboratory pain measurement procedures, TMS treatment parameters, sophistication of the sham methods, and sample sizes. METHODS This study used a sham-controlled, within-subject, cross-over design to examine the effects of 5 different TMS treatment parameters across several quantitative sensory measures in a sample of healthy adult volunteers. Sixty-five participants underwent quantitative sensory testing procedures pre and post-40-minutes of real and sham motor cortex TMS. TMS was delivered at 1 Hz 80% resting motor threshold (rMT), 1 Hz 100% rMT, 10 Hz 80% rMT, 10 Hz 100% rMT, or 50 Hz triplets at 90% of active motor threshold (intermittent theta-burst). RESULTS The mean painfulness rating of real TMS stimulation itself was 3.0 (SE=0.36) out of 10 and was significantly greater than zero [t(64)=8.17, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|