Clinical outcomes of transverse myelitis with myelin oligodendrocyte glycoprotein antibody versus negative cases among adults in Isfahan, Iran: A comparative study
| Autor: | Ahmad Chitsaz, Mahdieh Afzali, Hossein Tavakoli, Sahebeh Rajabkhah, Masoud Etemadifar, Arezoo Shafieyoun, Pegah Noorshargh |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Neurology Transverse myelitis Immunoglobulin G Myelin oligodendrocyte glycoprotein immune system diseases Internal medicine medicine Myelin Oligodendrocyte Glycoprotein Transverse Myelitis Expanded Disability Status Scale biology medicine.diagnostic_test business.industry Neuromyelitis Optica Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging nervous system diseases biology.protein Original Article Neurology (clinical) Antibody business Cohort study |
| Zdroj: | Current Journal of Neurology |
| ISSN: | 2717-011X |
| Popis: | Background: The aim of this study was to evaluate the status of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in patients with transverse myelitis (TM) and compare the clinical and imaging characteristics of MOG immunoglobulin G (IgG)-positive with negative cases. Methods: This cohort study enrolled 71 patients diagnosed with new-onset of TM who were being followed at a referral university clinic in Isfahan, Iran, from November 2016 to January 2019. Magnetic resonance imaging (MRI) images and blood samples for anti-MOG, anti-aquaporin 4 (anti-AQP4) (using the cell-based technique), and vasculitis-related antibodies were collected from patients. Outcomes were assessed by the evolution of the Expanded Disability Status Scale(EDSS) score and brain and spinal cord imaging findings within three months. All patients underwent imaging and clinical assessment during a mean period of one year as a follow-up. We compared the characteristics of clinical and radiological outcomes in MOG-IgG-positive and negative cases. Results: Of the total population studied, there were 26.8% men and 73.2% women, with a mean age of 33 ± 10 years. 12 (16.9%) patients were seropositive for MOG antibody and 17 (89.5%) were positive for anti-AQP4 antibodies. There was no significant association between anti-MOG antibody seropositivity and age, gender distribution, the presence of other autoimmune diseases, and number and interval of relapses. However, the involvement site of the spine at first imaging was significantly different between seronegative and seropositive patients. Conclusion: In patients with MOG antibody disease (MOG-AD) TM, the MRI findings suggest a preferential involvement of the cervical-thoracic section in seropositive cases which may help differentiate from non-MOG demyelination TM. |
| Databáze: | OpenAIRE |
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