Cell-mediated immunity and lymphocyte populations in experimental Argentine hemorrhagic fever (Junín Virus)
| Autor: | M J Frigerio, J R Oubiña, S N Rondinone, B Elsner, G Carballal |
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| Rok vydání: | 1981 |
| Předmět: |
Rosette Formation
T-Lymphocytes Lymphocyte Guinea Pigs Immunology Spleen Argentine hemorrhagic fever Microbiology Hemorrhagic Fever American Virus Leukocyte Count Immune system medicine Animals Hypersensitivity Delayed Arenaviruses New World B-Lymphocytes biology Tuberculin Test biology.organism_classification medicine.disease Virology Infectious Diseases medicine.anatomical_structure Lymphatic system Delayed hypersensitivity Junin virus Parasitology Lymph Nodes Research Article |
| Zdroj: | Infection and Immunity. 34:323-327 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.34.2.323-327.1981 |
| Popis: | Guinea pigs infected with the XJ prototype strain of Junín virus reproduce the main features of Argentine hemorrhagic fever, showing hemorrhages, leukothrombocytopenia, and focal lymphoid tissue necrosis. Viral lymphotropism is shown by the presence of viral antigens, severe cytopathic effect, and high virus titers in lymphoid organs. A pronounced depression of humoral immune response to sheep erythrocytes as well as to the virus is described. This study was carried out to determine whether cellular immune response was also modified and which cell populations were affected. Delayed hypersensitivity skin reaction to purified protein derivative was found to be markedly depressed after infection. A noticeable decrease in both percentages and absolute T lymphocyte numbers, detected by E rosettes, in spleen and lymph nodes, together with a low absolute T cell number in peripheral blood, were observed. Total cell counts in spleen, lymph nodes, and peripheral blood were also reduced. On the contrary, no modification in percentages of B lymphocytes, as measured by EAC rosettes, was found. These results indicate that cell-mediated immunity is markedly impaired in guinea pigs infected with the XJ strain of Junín virus. Its relationship with the pathogenesis of the disease is discussed. |
| Databáze: | OpenAIRE |
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