Anti-oxidant, DNA-damage protection and anti-cancer properties of n-butanol extract of the endemic Perralderia coronopifolia
| Autor: | Tevfik Ozen, Djamila Zama, Serkan Koldas, Samir Benayache, Fadila Benayache, Khadidja Bekhouche, Somia Lassed, Ibrahim Demirtas, Sara Boussaha, Semiha Yenigun |
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| Přispěvatelé: | OMÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
DNA protection
Metal chelating activity Antioxidant oxidative DNA-damage inhibition DNA damage DPPH medicine.medical_treatment Flavonoid Perralderia coronopifolia Coss antioxidant activity Phenolic content 010501 environmental sciences 01 natural sciences HeLa chemistry.chemical_compound medicine Food science Hydrogen peroxide 0105 earth and related environmental sciences Pharmacology chemistry.chemical_classification biology lcsh:RM1-950 biology.organism_classification anticancer activity lcsh:Therapeutics. Pharmacology chemistry flavonoids |
| Zdroj: | Bangladesh Journal of Pharmacology, Vol 13, Iss 1 (2018) |
| Popis: | Koldas, Serkan/0000-0002-7917-4008; Zama, D/0000-0002-4312-7701; Yenigun, Semiha/0000-0002-1979-5427 WOS: 000430194400001 This study was designed to evaluate in vitro the total phenolic, flavonoid content, anti-oxidant activity, oxidative DNA-damage protection and anti-cancer activity of n-butanol extract from Perralderia coronopifolia, endemic plant. DNA protection capacity was performed using 46966 plasmid DNA against UV-photolysis of H2O2-induced oxidative damage. The anti-prolifer-ative effects of extract were performed on HeLa and C6 cells. Experimental results showed that extract had convenient number of phenolic and flavonoids. Furthermore, it provided strong anti-oxidant, reducing power, hydrogen peroxide and higher DPPH? scavenging ability with IC50= 7.02 +/- 0.02 mu g/mL. As it shown an oxidative plasmid DNA-damage inhibition against UV-photolysis of H2O2, an anti-cancer activity athigher concentrations in cells. The data obtained that P. coronopifolia extract could be useful in human protection against infection and degenerative illness. Algerian Ministry of Higher Education; Turkish State Planning Organization [DPT2010K120720]; Cankiri Karatekin UniversityCankiri Karatekin University [FF080515B30]; Ondokuz Mayis UniversityOndokuz Mayis University [PYO.FEN.1904.13.003] This study was supported by the grants from the Algerian Ministry of Higher Education, Turkish State Planning Organization (DPT2010K120720), Cankiri Karatekin University (BAP Project: FF080515B30) and Ondokuz Mayis University (BAP Project: PYO.FEN.1904.13.003). |
| Databáze: | OpenAIRE |
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