Immunity traits in pigs: substantial genetic variation and limited covariation
| Autor: | Marcel Bouffaud, Yu Gao, Jean-Jacques Leplat, Angélique Teillaud, Isabelle P. Oswald, Claire Rogel-Gaillard, Joëlle Laffitte, Gaetan Lemonnier, Denis Laloë, Christiane de Vaureix, Laurence Flori, Anne-Marie Cossalter, Jean Pierre Bidanel, Marie-José Mercat, Philippe Pinton, François Lefèvre |
|---|---|
| Přispěvatelé: | Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Unité de recherche Pharmacologie-Toxicologie (UPT), Institut National de la Recherche Agronomique (INRA), Unité de recherche Virologie et Immunologie Moléculaires (VIM), Unité Expérimentale de Testage de Porcs, Pôle Amélioration de l'animal, Institut du Porc, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Unité expérimentale de testage de porcs, Institut du Porc (IFIP), AgroParisTech-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences deoxynivalenol lcsh:Medicine Lymphocyte proliferation Adaptive Immunity medicine.disease_cause paramètre Genetics of the Immune System sélection lcsh:Science Immune Response innate immunity large white Animal Management immune trait Swine Diseases 2. Zero hunger Genetics Principal Component Analysis 0303 health sciences Multidisciplinary response Vaccination Mycoplasma hyopneumoniae 04 agricultural and veterinary sciences Pneumonia of Swine Mycoplasmal Flow Cytometry Phenotype parameter Cytokines Female performance Research Article Veterinary Medicine Genetic Markers Immunology lymphocyte sanguin selection Biology Veterinary Immunology 03 medical and health sciences breeding resistance to pathogen livestock blood lymphocyte cell swine pathogène Genetic variation Heredity medicine Animals Selection Genetic 030304 developmental biology Animal Performance Innate immune system lcsh:R 0402 animal and dairy science Genetic Variation Robustness (evolution) Heritability élevage 040201 dairy & animal science Immunity Innate Genetic marker Veterinary Science lcsh:Q cellule Animal Genetics |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2011, 6, online (7), Non paginé. ⟨10.1371/journal.pone.0022717⟩ PLoS ONE, Vol 6, Iss 7, p e22717 (2011) Plos One 7 (6, online), Non paginé. (2011) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0022717⟩ |
| Popis: | Chantier qualité GA; Background: Increasing robustness via improvement of resistance to pathogens is a major selection objective in livestock breeding. As resistance traits are difficult or impossible to measure directly, potential indirect criteria are measures of immune traits (ITs). Our underlying hypothesis is that levels of ITs with no focus on specific pathogens define an individual's immunocompetence and thus predict response to pathogens in general. Since variation in ITs depends on genetic, environmental and probably epigenetic factors, our aim was to estimate the relative importance of genetics. In this report, we present a large genetic survey of innate and adaptive ITs in pig families bred in the same environment.[br/] Methodology/Principal Findings: Fifty four ITs were studied on 443 Large White pigs vaccinated against Mycoplasma hyopneumoniae and analyzed by combining a principal component analysis (PCA) and genetic parameter estimation. ITs include specific and non specific antibodies, seric inflammatory proteins, cell subsets by hemogram and flow cytometry, ex vivo production of cytokines (IFNa, TNFa, IL6, IL8, IL12, IFNc, IL2, IL4, IL10), phagocytosis and lymphocyte proliferation. While six ITs had heritabilities that were weak or not significantly different from zero, 18 and 30 ITs had moderate (0.1,h2#0.4) or high (h2.0.4) heritability values, respectively. Phenotypic and genetic correlations between ITs were weak except for a few traits that mostly include cell subsets. PCA revealed no cluster of innate or adaptive ITs. [br/] Conclusions/Significance: Our results demonstrate that variation in many innate and adaptive ITs is genetically controlled in swine, as already reported for a smaller number of traits by other laboratories. A limited redundancy of the traits was also observed confirming the high degree of complementarity between innate and adaptive ITs. Our data provide a genetic framework for choosing ITs to be included as selection criteria in multitrait selection programmes that aim to improve both production and health traits. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|