7α-Hydroxy-Dehydroepiandrosterone and Immune Response
| Autor: | V Chmielewski, Pierre Lafaye, Denis Pompon, Farida Nato, Robert Morfin, Anne-Cécile Cotillon |
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| Přispěvatelé: | Conservatoire National des Arts et Métiers [CNAM] (CNAM), Institut Pasteur [Paris], Centre National de la Recherche Scientifique (CNRS), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Lymphoid Tissue Dehydroepiandrosterone Epiandrosterone General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Paracrine signalling Mice 0302 clinical medicine Immune system History and Philosophy of Science Immunity Internal medicine medicine Animals Humans MESH: Animals MESH: Mice MESH: Immunity 030304 developmental biology 0303 health sciences MESH: Humans biology General Neuroscience Cytochrome P450 3. Good health MESH: Hydroxytestosterones Lymphatic system Endocrinology [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology 030220 oncology & carcinogenesis MESH: Lymphoid Tissue Pregnenolone biology.protein Hydroxytestosterones medicine.drug |
| Zdroj: | Annals of the New York Academy of Sciences Annals of the New York Academy of Sciences, Wiley, 2000, 917 (1), pp.971-982. ⟨10.1111/j.1749-6632.2000.tb05464.x⟩ Annals of the New York Academy of Sciences, 2000, 917 (1), pp.971-982. ⟨10.1111/j.1749-6632.2000.tb05464.x⟩ |
| ISSN: | 0077-8923 1749-6632 |
| DOI: | 10.1111/j.1749-6632.2000.tb05464.x⟩ |
| Popis: | International audience; In human and murine lymphoid organs, circulating 3 beta-hydroxysteroids, including pregnenolone (PREG), dehydroepiandrosterone (DHEA), and epiandrosterone (EPIA), are 7 alpha-hydroxylated by a cytochrome P450 identified in the hippocampus as P4507B1. Mouse and human lymphoid organs produced different patterns of 3 beta-hydroxysteroid 7 alpha-hydroxylation with the absence of pregnenolone and epiandrosterone hydroxylation in human and mouse, respectively. Both 7 alpha-hydroxy-DHEA and 7 alpha-hydroxy-EPIA triggered a significant increase of antitetanus toxoid and anti-Bordetella pertussis toxins IgGs production in cultures of activated B + T cells derived from human tonsils, whereas both 7 alpha-hydroxy-PREG and 7 alpha-hydroxy-DHEA increased the immune response in mouse. Paracrine action of 7 alpha-hydroxysteroids resulted from their production in cells of the lymphoid organs. Comparison of P4507B1 sequences in rat, human, and two mouse species showed that one amino acid change might explain important differences in KM for 7 alpha-hydroxylation, and suggested that such differences might contribute to the extent of immune response. |
| Databáze: | OpenAIRE |
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