Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage
| Autor: | Meishan Xiong, Yupeng Zhang, Yi Zeng, Ruijuan Chen, Wenbiao Xiao, Yi Shu, Jianyi Liu, Hongyu Long, Le Zhang, Sai Wang, Lei Chen, Xueli Wei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Immunology Biology Asian People medicine Immunology and Allergy Humans Epigenetics cardiovascular diseases Gene Whole blood Original Research Aged Cerebral Hemorrhage Intracerebral hemorrhage DNA methylation epigenetics Promoter Methylation Middle Aged RC581-607 medicine.disease epigenome-wide association study intracerebral hemorrhage stroke nervous system diseases genomic DNA Case-Control Studies Female Immunologic diseases. Allergy Biomarkers Genome-Wide Association Study |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.702244/full |
| Popis: | Primary intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality throughout the world. ICH is a multifactorial disease that emerges from interactions among multiple genetic and environmental factors. DNA methylation plays an important role in the etiology of complex traits and diseases. We used the Illumina Infinium Human Methylation 850k BeadChip to detect changes in DNA methylation in peripheral blood samples from patients with ICH and healthy controls to explore DNA methylation patterns in ICH. Here, we compared genomic DNA methylation patterns in whole blood from ICH patients (n = 30) and controls (n = 34). The ICH and control groups showed significantly different DNA methylation patterns at 1530 sites (p-value < 5.92E-08), with 1377 hypermethylated sites and 153 hypomethylated sites in ICH patients compared to the methylation status in healthy controls. A total of 371 hypermethylated sites and 35 hypomethylated sites were in promoters, while 738 hypermethylated sites and 67 hypomethylated sites were in coding regions. Furthermore, the differentially methylated genes between ICH patients and controls were largely related to inflammatory pathways. Abnormalities in the DNA methylation pattern identified in the peripheral blood of ICH patients may play an important role in the development of ICH and warranted further investigation. |
| Databáze: | OpenAIRE |
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