Ilex paraguariensis (A. St.-Hil.) leaf infusion decreases iron absorption in patients with hereditary hemochromatosis: a randomized controlled crossover study
| Autor: | Hanna Pillmann Ramos, Edson Luiz da Silva, Francilene Gracieli Kunradi Vieira, Bruno Vieira Dias, Vivian Karla Brognoli Franco, Cristiane Manfé Pagliosa |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Iron Overload Absorption (skin) Gastroenterology Beverages 03 medical and health sciences 0302 clinical medicine Ilex paraguariensis Internal medicine medicine Humans Adverse effect Aged Meal Cross-Over Studies medicine.diagnostic_test Plant Extracts business.industry Area under the curve General Medicine Middle Aged Crossover study Plant Leaves 030104 developmental biology Postprandial Hereditary hemochromatosis Serum iron Female 030211 gastroenterology & hepatology Hemochromatosis business Food Science |
| Zdroj: | Food & Function. 12:7321-7328 |
| ISSN: | 2042-650X 2042-6496 |
| DOI: | 10.1039/d1fo00482d |
| Popis: | This study proposed to investigate the effect of Ilex paraguariensis infusion on the absorption of non-heme iron in hereditary hemochromatosis (HH) patients with the HFE genotype. A two-way randomized, controlled, crossover trial was conducted on patients, aged 29-69 years, undergoing maintenance therapy. Fourteen HFE-HH patients ingested a meal containing 11.4 mg iron and 200 mL either of water (control) or of Ilex paraguariensis leaf infusion. The beverages were offered in random order, at intervals separated by a washout period of 7 days. Active surveillance showed no adverse effects. Blood samples were drawn shortly before and 1, 2, 3, and 4 h after the meal for serum iron measurement. A significant reduction in the postprandial serum iron was observed for HH patients after intake of the Ilex paraguariensis infusion (area under the curve (AUC) expressed as mean ± SEM: 173.3 ± 44.7 μmol h-1 L-1) compared to water (1449.4 ± 241.5 μmol h-1 L-1) (p < 0.001). In summary, intake of Ilex paraguariensis leaf infusion significantly inhibited the absorption of iron in patients with HH and, therefore, should be considered as a potential adjuvant for iron overload control. |
| Databáze: | OpenAIRE |
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