Natural killer cell monitoring in cutaneous melanoma - new dynamic biomarker
| Autor: | Gheorghița Isvoranu, Monica Neagu, Ovidiu Gabriel Bratu, Mihaela Surcel, Adriana Munteanu, Radu-Ionuț Huică, Carolina Constantin, Cornel Ursaciuc, Dan Ciotaru, Ioana Ruxandra Pîrvu |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Spleen NK cells Natural killer cell 03 medical and health sciences 0302 clinical medicine Immune system medicine melanoma B-lymphocytes tumor-bearing mice T-lymphocytes business.industry Melanoma Cancer Articles Cell cycle medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cutaneous melanoma Cancer research Skin cancer business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | Melanoma is responsible for most skin cancer deaths in humans. The immune system plays a major role in regulating tumor cell proliferation by initiating defence responses against tumor aggression. Research on murine cancer models allow for a better understanding of immune response in malignancies, revealing specific changes of the immune status in the presence of tumors. Melanoma resistance to conventional therapies and its high immunogenicity justify the development of new therapies. These features reinforce melanoma as a suitable model for studying antitumor immunity. Recent findings on NK cell activation in cancer patients indicate that several important parameters, such as tumor capacity to modulate the function and phenotype of NK cells, require consideration for the choice of an NK-based therapy. In this study, we investigated T-CD4+ and T-CD8+ lymphocytes, B lymphocytes and NK cells in peripheral blood and spleen cells suspension from melanoma-bearing mice compared to healthy controls in order to assess the potential for tumor growth-promoting immunosuppression. Our results indicate that in a melanoma-bearing mouse model the percentage of NK cells in spleen is reduced and that their phenotype is different compared to control mouse NK cells. |
| Databáze: | OpenAIRE |
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