Detection of macrocyclic lactones in porcine liver, meat and fish tissue using LC–APCI–MS–MS

Autor:	Herlinde Noppe, K. Verheyden, Klaas Wille, Hubert De Brabander, Julie Vanden Bussche
Přispěvatelé:	Veterinary Public Health and Food Safety, Universiteit Gent = Ghent University [Belgium] (UGENT)
Rok vydání:	2009
Předmět:	Health Toxicology and Mutagenesis Atmospheric-pressure chemical ionization 02 engineering and technology Toxicology Mass spectrometry 01 natural sciences chemistry.chemical_compound Liquid chromatography–mass spectrometry medicine Doramectin Emamectin Chromatography Chemistry 010401 analytical chemistry Public Health Environmental and Occupational Health Life Sciences General Chemistry General Medicine Repeatability 021001 nanoscience & nanotechnology 0104 chemical sciences Milbemycin Abamectin 0210 nano-technology Food Science medicine.drug
Zdroj:	Food Additives and Contaminants Food Additives and Contaminants, 2009, 26 (09), pp.1232-1238. ⟨10.1080/02652030903046674⟩
ISSN:	1944-0057 1944-0049
DOI:	10.1080/02652030903046674
Popis:	A selective and sensitive method for the simultaneous determination of five avermectins (abamectin, ivermectin, doramectin, emamectin and eprinomectin) and one milbemycin (moxidectin) in porcine liver, bovine meat and fish tissue was developed. The method involved extraction with acetonitrile and purification by C18 solid-phase extraction. Detection was carried out using liquid chromatography coupled to multiple mass spectrometry (LC–MS2) equipped with APCI in the negative mode. This method was validated according to the requirements of Commission Decision EC/2002/657 (Implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off J Eur Commun. L221: 8–36.). In addition to the linear response (R 2 between 59 and 97%), good repeatability (CV between 20 and 35%), reproducibility (CV between 20 and 35%) and detection (CCα) and quantification (CCβ) limits were obtained for all compounds in all matrices considered.
Databáze:	OpenAIRE
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