The relative transmission of the fractions of papain hydrolyzed homologous γ-globulin from the uterine cavity to the foetal circulation in the rabbit
| Autor: | C. L. Oakley, W. A. Hemmings, Francis William Rogers Brambell, Rodney R. Porter |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Globulin
Fraction (chemistry) chemistry.chemical_compound Fetus Antigen Papain Homologous chromosome Animals Humans Physiological Phenomena General Environmental Science biology Uterus General Engineering Rabbit (nuclear engineering) Gamma globulin Fetal Blood Biochemistry chemistry biology.protein General Earth and Planetary Sciences Female Rabbits gamma-Globulins Antibody |
| Zdroj: | Proceedings of the Royal Society of London. Series B. Biological Sciences. 151:478-482 |
| ISSN: | 2053-9193 0080-4649 |
| DOI: | 10.1098/rspb.1960.0011 |
| Popis: | Molecules of rabbit γ-globulin are split into three nearly equal pieces by papain. Trace labelled with 131 I these three fractions are transmitted by the yolk-sac to the circulation of the 24-day rabbit foetus in significantly different quantities. Fraction III is transmitted nearly as readily as whole γ-globulin, whereas fractions II and I are transmitted only 1/5 and 1/10 as readily, respectively, as fraction III. It is suggested that fraction III, which contains most of the antigenic groups of the original molecules, also has the configuration recognized by the cells as homologous γ-globulin. |
| Databáze: | OpenAIRE |
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