Transcriptomic responses of peripheral blood cells to coronary artery disease
Autor: | Ming-shan Lin, Yi-fan Chi, Yuan Zhang, Qiang Huang, Zhaozhuo Niu |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Health (social science) CAD Coronary Artery Disease 030204 cardiovascular system & hematology Bioinformatics General Biochemistry Genetics and Molecular Biology Transcriptome Coronary artery disease 03 medical and health sciences 0302 clinical medicine Circular RNA microRNA Gene expression medicine Humans RNA Messenger cardiovascular diseases Blood Cells business.industry General Medicine medicine.disease Non-coding RNA MicroRNAs 030104 developmental biology RNA Long Noncoding Personalized medicine business Biomarkers |
Zdroj: | BioScience Trends. 12:354-359 |
ISSN: | 1881-7823 1881-7815 |
DOI: | 10.5582/bst.2018.01078 |
Popis: | Transcriptomic response of peripheral blood cells to coronary artery diseases (CAD) is a long recognized phenomenon. Currently, accumulating evidence indicates that such response having significant clinical utility in CAD-associated events determination. In this review, we summarized the existing data of transcriptomic biomarkers at mRNA, microRNA, long non-coding RNA, and circular RNA for the diagnosis, progression and outcome prediction and treatment response of CAD. Furthermore, we also discussed the functional significance on the gene expression patterns caused by CAD, and emphasized the importance of inflammatory pathways in CAD tissues-blood cells interaction. Based on the current knowledge, we proposed a perspective on the future strategies to further improve the robustness and reproducibility of transcriptomic biomarkers in the personalized medicine of CAD patients. |
Databáze: | OpenAIRE |
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