Polymorphisms in Inflammation Genes and Bladder Cancer: From Initiation to Recurrence, Progression, and Survival
| Autor: | Seth P. Lerner, Jian Gu, Qiong Dong, Yunfei Wang, Dan Leibovici, R. E. Millikan, Colin P.N. Dinney, H. Barton Grossman, Xifeng Wu |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Peroxisome proliferator-activated receptor gamma Genotype Single-nucleotide polymorphism medicine.disease_cause Risk Factors Internal medicine medicine Humans Survival analysis Aged Proportional Hazards Models Inflammation Chi-Square Distribution Polymorphism Genetic Bladder cancer Interleukin-6 Tumor Necrosis Factor-alpha business.industry Interleukin-8 Case-control study Middle Aged medicine.disease Survival Analysis PPAR gamma Logistic Models Urinary Bladder Neoplasms Tumor progression Case-Control Studies Immunology Disease Progression Female Neoplasm Recurrence Local Carcinogenesis business |
| Zdroj: | Journal of Clinical Oncology. 23:5746-5756 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2005.01.598 |
| Popis: | Purpose Since chronic inflammation contributes to tumorigenesis, we hypothesized that the risk and clinical outcome of bladder cancer (BC) might be modulated by genetic variations in inflammation genes. Methods Using the TaqMan method, we genotyped single nucleotide polymorphisms in interleukin (IL) -6 (−174 G→C), IL-8 (−251 T→A), tumor necrosis factor-alpha (TNF-α; −308 G→A), and peroxisome proliferator-activated receptor γ (PPARG; Pro12Ala), and determined their associations with BC initiation and clinical outcome. Results We found that the IL-6 variant genotype (C/C) was associated with an increased BC risk (OR, 1.77; 95% CI, 1.25 to 2.51). There were joint effects between the variant IL-6 genotypes and smoking status, and between the variant genotypes of IL-6 and other genes. To assess effect on recurrence, we grouped non-muscle-invasive BC patients according to intravesical Bacillus Calmette-Guerin (BCG) treatment status: no BCG, induction BCG (iBCG), and maintenance BCG (mBCG). In the Cox proportional hazards model, the variant IL-6 genotype was associated with an increased recurrence risk (hazard ratio [HR], 4.60; 95% CI, 1.24 to 17.09) in patients receiving mBCG. The variant PPARG genotype was associated with a reduced recurrence risk (HR, 0.41; 95% CI, 0.20 to 0.86) among untreated patients. In patients with non-muscle-invasive BC, the variant IL-6 genotype was associated with an increased progression risk (HR, 1.88; 95% CI, 0.80 to 4.11). In patients with invasive BC, variant IL-6 was associated with improved 5-year overall and disease-specific survival (HR, 0.43; 95% CI, 0.19 to 0.94 and HR, 0.39; 95% CI, 0.15 to 1.00, respectively). Conclusion Inflammation gene polymorphisms are associated with modified BC risk, treatment response, and survival. |
| Databáze: | OpenAIRE |
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