Comparison of T2*-weighted and QSM contrasts in Parkinson's disease to visualize the STN with MRI
| Autor: | David R. Weise, Andreas Schäfer, Max C. Keuken, Sonja A. Kotz, Johannes Schwarz, Gilles de Hollander, Anneke Alkemade, Birte U. Forstmann, Derek V. M. Ott |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), RS: FPN NPPP I, Section Neuropsychology |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology Parkinson's disease Vision Physiology Deep Brain Stimulation medicine.medical_treatment Social Sciences lcsh:Medicine Signal-To-Noise Ratio Diagnostic Radiology 030218 nuclear medicine & medical imaging 0302 clinical medicine Nuclear magnetic resonance Medicine and Health Sciences Psychology Right Hemisphere lcsh:Science Aged 80 and over Brain Mapping Movement Disorders Multidisciplinary medicine.diagnostic_test Radiology and Imaging Brain Contrast (statistics) Parkinson Disease Neurodegenerative Diseases Quantitative susceptibility mapping Middle Aged Magnetic Resonance Imaging Electrophysiology Subthalamic nucleus Bioassays and Physiological Analysis Data Acquisition Neurology Brain Electrophysiology Female Sensory Perception Disease Susceptibility Anatomy T2 weighted Research Article Computer and Information Sciences medicine.medical_specialty Deep brain stimulation Imaging Techniques Neurophysiology Surgical and Invasive Medical Procedures Neuroimaging Research and Analysis Methods 03 medical and health sciences Subthalamic Nucleus Diagnostic Medicine Journal Article medicine Humans Aged business.industry Electrophysiological Techniques lcsh:R Biology and Life Sciences Magnetic resonance imaging medicine.disease Case-Control Studies lcsh:Q business Cerebral Hemispheres Deep-Brain Stimulation 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS One PLoS ONE, Vol 12, Iss 4, p e0176130 (2017) PLoS One, 12(4):e0176130. Public Library of Science PLOS ONE, 12(4):e0176130. Public Library of Science PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The subthalamic nucleus (STN) plays a crucial role in the surgical treatment of Parkinson's disease (PD). Studies investigating optimal protocols for STN visualization using state of the art magnetic resonance imaging (MRI) techniques have shown that susceptibility weighted images, which display the magnetic susceptibility distribution, yield better results than T-1-weighted, T-2-weighted, and T-2*-weighted contrasts. However, these findings are based on young healthy individuals, and require validation in elderly individuals and persons suffering from PD. Using 7T MRI, the present study set out to investigate which MRI contrasts yielded the best results for STN visualization in 12 PD patients and age-matched healthy controls (HC). We found that STNs were more difficult to delineate in PD as reflected by a lower inter-rater agreement when compared to HCs. No STN size differences were observed between the groups. Analyses of quantitative susceptibility mapping (QSM) images showed a higher inter-rater agreement reflected by increased Dice-coefficients. The location of the center of mass of the STN was not affected by contrast. Overall, contrast-to-noise ratios (CNR) were higher in QSM than in T-2*-weighted images. This can at least partially, explain the higher inter-rater agreement in QSM. The current results indicate that the calculation of QSM contrasts contributes to an improved visualization of the entire STN. We conclude that QSM contrast is the preferred choice for the visualization of the STN in persons with PD as well as in aging HC. |
| Databáze: | OpenAIRE |
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