Successful treatment of Raynaud's phenomenon and digital ulcers in systemic sclerosis patients with botulinum toxin B injection: Assessment of peripheral vascular disorder by angiography and dermoscopic image of nail fold capillary
Autor: | Shintaro Saito, Hirohisa Ishibuchi, Akiko Sekiguchi, Sei‐ichiro Motegi, Masahito Yasuda, Chikako Kishi, Osamu Ishikawa |
---|---|
Rok vydání: | 2017 |
Předmět: |
Adult
medicine.medical_specialty Acetylcholine Release Inhibitors Dermoscopy Dermatology complex mixtures Injections Microscopic Angioscopy Fingers 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Skin Ulcer medicine Humans RAYNAUD DISEASE Increased blood flow Botulinum Toxins Type A skin and connective tissue diseases Aged 030203 arthritis & rheumatology Scleroderma Systemic integumentary system medicine.diagnostic_test Peripheral blood flow business.industry Angiography Raynaud Disease General Medicine Skin ulcer Botulinum toxin Nail fold Peripheral Vascular Disorder Capillaries Treatment Outcome Female medicine.symptom business medicine.drug |
Zdroj: | The Journal of dermatology. 45(3) |
ISSN: | 1346-8138 |
Popis: | We recently identified the efficacy and safety of a botulinum toxin (BTX)-A/B in Raynaud's phenomenon (RP) and digital ulcers (DU) in Japanese patients with systemic sclerosis (SSc). Detailed assessments of peripheral vascular disorder using angiography and dermoscopic images of nail fold capillaries have not been performed previously. This study aimed to evaluate the effect of BTX-B on SSc-associated peripheral vascular disorder. Two SSc patients who suffered with RP and DU were treated with a BTX-B injection, and thereafter the symptoms of RP were improved and DU healed in both patients. Furthermore, angiography showed an increased blood flow to the palm and fingers, and dermoscopic images of nail fold capillary changes showed improvement. These results suggest that a BTX-B injection may increase peripheral blood flow and improve RP and DU in SSc patients. |
Databáze: | OpenAIRE |
Externí odkaz: |