Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus
| Autor: | Taichi Kashiwagi, Takeki Hamasaki, Sanetaka Shirahata, Takaaki Komatsu, Yuping Li, Noboru Nakamichi, Yoshitoki Ishii, Tomoya Kinjo, Zbigniew Gadek, Hanxu Yan, Kiichiro Teruya |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Biomedical Engineering Type 1 diabetes mellitus Bioengineering Apoptosis Biology HIT-T15 cells Superoxide dismutase chemistry.chemical_compound Internal medicine Alloxan Diabetes mellitus medicine Cytotoxic T cell chemistry.chemical_classification Reactive oxygen species JAACT Special Issue Cell Biology medicine.disease Endocrinology chemistry Catalase Immunology biology.protein DNA fragmentation Natural reduced water Biotechnology |
| Zdroj: | Cytotechnology |
| ISSN: | 1573-0778 0920-9069 |
| Popis: | Insulin-producing cells express limited activities of anti-oxidative enzymes. Therefore, reactive oxygen species (ROS) produced in these cells play a crucial role in cytotoxic effects. Furthermore, diabetes mellitus (DM) development is closely linked to higher ROS levels in insulin-producing cells. Hita Tenryosui Water® (Hita T. W., Hita, Japan) and Nordenau water (Nord. W., Nordenau, Germany), referred to as natural reduced waters (NRWs), scavenge ROS in cultured cells, and therefore, might be a possibility as an alternative to conventional pharmacological agents against DM. Therefore, this study aimed to investigate the role of NRWs in alloxan (ALX)-induced β-cell apoptosis as well as in ALX-induced diabetic mice. NRWs equally suppressed DNA fragmentation levels. Hita T. W. and Nord. W. ameliorated ALX-induced sub-G1 phase production from approximately 40% of control levels to 8.5 and 11.8%, respectively. NRWs restored serum insulin levels (p |
| Databáze: | OpenAIRE |
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