Differential Expression of Cancer-Associated Proteins in Breastmilk
| Autor: | Ramak Amjad, Ke Zhang, Wenyi Qin, Beth Kliethermes, Kaitlin Clarke, Edward R. Sauter |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Basic fibroblast growth factor Breast Neoplasms Weaning Lipocalin Pediatrics Transforming Growth Factor beta1 Transforming Growth Factor beta2 chemistry.chemical_compound Breast cancer Lipocalin-2 Pregnancy Proto-Oncogene Proteins Lactation Internal medicine Maternity and Midwifery medicine Humans Milk Human business.industry Health Policy Age Factors Infant Newborn Obstetrics and Gynecology Cancer Milk Proteins medicine.disease Lipocalins Neoplasm Proteins Gene Expression Regulation Neoplastic Parity Endocrinology medicine.anatomical_structure chemistry Female Fibroblast Growth Factor 2 Kallikreins business Acute-Phase Proteins Transforming growth factor |
| Zdroj: | Breastfeeding Medicine. 8:120-126 |
| ISSN: | 1556-8342 1556-8253 |
| Popis: | Breast cancer that develops during or shortly after pregnancy is frequently more aggressive than cancer diagnosed at other times in a woman's life. To better understand the patterns of cancer-related protein expression in the breasts of lactating women, we determined the differences in total and individual protein expression in milk based on (a) three time points during lactation (early, mid, and late), (b) length of lactation, and (c) parity. Breastmilk was collected from 72 healthy lactating women within 10 days of starting lactation (transitional [T]), 2 months after lactation started, and during breast weaning (W). Sixteen proteins whose expression is altered in breast cancer (11 kallikreins [KLKs], basic fibroblast growth factor [bFGF], YKL-40, neutrophil gelatinase-associated lipocalin, and transforming growth factor [TGF] β1 and β2) were evaluated. The concentration of total milk protein decreased over time (p0.01 at 2 months and W compared with T). After we controlled for total protein, KLK6 and TGFβ2 significantly increased, and bFGF decreased from T to W. Neither length of nursing nor parity significantly influenced individual protein expression at the W time point. On the other hand, length of nursing did influence the difference in KLK6, -7, and -8 expression between the W and T time points. Total milk protein concentration is lower in the mid and late phases of nursing. Biomarker differences between T and W milk samples in KLK6, TGFβ2, and bFGF are consistent with a protective effect of nursing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|