Severe disabling sensory-motor polyneuropathy during oxaliplatin-based chemotherapy
| Autor: | Jean L. Grem, Michael Wagner, Mary G. Quinn, Gregory D. Leonard |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Sensory axonal neuropathy Organoplatinum Compounds Colorectal cancer medicine.medical_treatment Sensory system Deoxycytidine Severity of Illness Index Capecitabine Polyneuropathies Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Disabled Persons Pharmacology (medical) Pharmacology Chemotherapy business.industry Combination chemotherapy Middle Aged medicine.disease Oxaliplatin Colonic Neoplasms Fluorouracil business Polyneuropathy medicine.drug |
| Zdroj: | Anti-Cancer Drugs. 15:733-735 |
| ISSN: | 0959-4973 |
| Popis: | Oxaliplatin-based combination chemotherapy is an option for first-line therapy of metastatic colorectal cancer. It is associated with acute hyperexcitability of motor and sensory nerves, and a cumulative sensory axonal neuropathy. We describe a 56-year-old male with metastatic colorectal cancer treated with oxaliplatin and capecitabine who developed a rapidly ascending motor and sensory neuropathy, which rendered him wheelchair-bound. Heightened clinical suspicion for possible oxaliplatin-induced motor neuropathies may be warranted. |
| Databáze: | OpenAIRE |
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