Canalicular adenoma with unicystic morphology. A rare entity
| Autor: | Rania H. Younis, Andreas C. Lazaris, Nikolaos G. Nikitakis, Maria Georgaki, Efstathios Pettas, Vasileios-Ionas Theofilou, Argyrios Daskalopoulos, Demos Kalyvas |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Solitary pulmonary nodule Pathology medicine.medical_specialty Oral Medicine and Pathology biology CD117 business.industry Canalicular adenoma Case Report Context (language use) Columnar Cell medicine.disease Basal cell adenoma Gross examination 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis medicine biology.protein Differential diagnosis business General Dentistry UNESCO:CIENCIAS MÉDICAS |
| Zdroj: | Pettas, E., Theofilou, V. I., Georgaki, M., Daskalopoulos, A., Kalyvas, D., Lazaris, A. C., Younis, R. H., & Nikitakis, N. G. (2021). Canalicular adenoma with unicystic morphology. A rare entity. Journal of clinical and experimental dentistry, 13(1), e88–e94. Journal of Clinical and Experimental Dentistry |
| ISSN: | 1989-5488 |
| DOI: | 10.4317/jced.57646 |
| Popis: | Background Canalicular adenoma (CA) is a benign salivary gland tumor (SGT) almost exclusively affecting the minor salivary glands, predominantly of the upper lip, and exhibiting characteristic histopathologic features. As observed in several other SGTs, a commonly encountered finding is the presence of prominent cystic morphology. Even though a multicystic appearance is usually noticed, solitary cystic CAs may rarely occur. Case report Two female patients (74 and 78 years old respectively) presented for the evaluation of submucosal asymptomatic masses of the oral cavity. In the 1st case a solitary nodule was noticed in the upper lip, while the 2nd patient exhibited two symmetrical lesions of the buccal mucosae. All three excised specimens displayed cystic morphology upon gross examination. Histopathologically, a solitary cystic formation lined by monomorphic cuboidal or basaloid cells arranged in solid or trabecular patterns was observed in the 1st case. With a differential diagnosis of CA vs basal cell adenoma immunohistochemical examination was performed. Positivity for S-100, CK7 and CD117 (c-kit) and negative reaction for GFAP, p63 and SMA rendered the diagnosis of CA. In the 2nd case both lesions displayed well-circumscribed proliferations by monotonous cuboidal or columnar cells arranged in single cords and occasionally forming beading patterns, while central solitary areas of marked cystic degeneration were noticed. Diagnosis of multifocal unicystic CA was disclosed. Discussion To our knowledge, only 11 additional cases of unicystic CA have been reported in the English-language literature. Although the exact clinical significance of unicystic morphology in CA is unknown, a tendency for occurrence within the context of multifocal tumors has been detected. Key words:Canalicular adenoma, monomorphic adenoma, unicystic morphology, multifocal tumors, minor salivary glands. |
| Databáze: | OpenAIRE |
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