Immunological and Viral Determinants of Dengue Severity in Hospitalized Adults in Ha Noi, Viet Nam

Autor: Trinh Thi Minh Lien, Pham Thi Khuong, Jeremy Farrar, Annette Fox, Peter Horby, Tran Thi Hai Ninh, Le Nguyen Minh Hoa, Marcel Wolbers, Walter R. J. Taylor, Heiman F. L. Wertheim, Nguyen Thi Nam Lien, Cameron P. Simmons, Nguyen Vu Trung, Nguyen Van Kinh, Nguyen Duc Hien
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Serotype
Male
viruses
Dengue virus
medicine.disease_cause
Severity of Illness Index
Serology
Dengue fever
Dengue
0302 clinical medicine
Cluster Analysis
Immunology/Cellular Microbiology and Pathogenesis
0303 health sciences
lcsh:Public aspects of medicine
virus diseases
Viral Load
3. Good health
Hospitalization
Infectious Diseases
Vietnam
RNA
Viral
Female
Viral load
Research Article
Adult
lcsh:Arctic medicine. Tropical medicine
Genotype
lcsh:RC955-962
Secondary infection
030231 tropical medicine
Molecular Sequence Data
Viremia
03 medical and health sciences
Immunology/Immunity to Infections
Virology
Severity of illness
Infectious Diseases/Viral Infections
medicine
Humans
Serotyping
030304 developmental biology
business.industry
Public Health
Environmental and Occupational Health
lcsh:RA1-1270
Sequence Analysis
DNA
biochemical phenomena
metabolism
and nutrition
Virology/Mechanisms of Resistance and Susceptibility
including Host Genetics
Dengue Virus
medicine.disease
Cross-Sectional Studies
Infectious Diseases/Neglected Tropical Diseases
Immunology
business
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e967 (2011)
ISSN: 1935-2735
1935-2727
Popis: Background The relationships between the infecting dengue serotype, primary and secondary infection, viremia and dengue severity remain unclear. This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi. Methods and Findings 158 patients were enrolled between September 16 and November 11, 2008. Quantitative RT-PCR, serology and NS1 detection were used to confirm dengue infection, determine the serotype and plasma viral RNA concentration, and categorize infections as primary or secondary. 130 (82%) were laboratory confirmed. Serology was consistent with primary and secondary infection in 34% and 61%, respectively. The infecting serotype was DENV-1 in 42 (32%), DENV-2 in 39 (30%) and unknown in 49 (38%). Secondary infection was more common in DENV-2 infections (79%) compared to DENV-1 (36%, p
Author Summary Dengue is estimated to affect 50 million people each year and can occur as explosive outbreaks that overwhelm health systems. Despite significant advances the available knowledge is not sufficient to predict the outcome of individual infections or the occurrence of epidemics. Studies from low dengue transmission settings are lacking but offer the potential to better understand the contribution of age, primary versus secondary infection and serotype because there are likely to be more adult and primary infection patients and fewer serotypes circulating compared to high transmission settings. This is the first reported study of clinical dengue in Ha Noi, the largest urban area of Northern Viet Nam. Records kept by the Preventive Medicine Center indicate that
Databáze: OpenAIRE
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