Decyanation–(hetero)arylation of malononitriles to access α-(hetero)arylnitriles

Autor:	L. Reginald Mills, Purvish Patel, Sophie A. L. Rousseaux
Rok vydání:	2022
Předmět:	Nitriles Organic Chemistry Indicators and Reagents Salts Physical and Theoretical Chemistry Biochemistry Catalysis
Zdroj:	Organic & Biomolecular Chemistry. 20:5933-5937
ISSN:	1477-0539 1477-0520
Popis:	Quaternary α-(hetero)arylnitriles are desirable biologically relevant products, however the existing methods for their synthesis can be unselective or require the use of undesirable reagents, such as cyanide salts. Herein we report a one-pot method for transnitrilation-mediated decyanation-metalation of disubstituted malononitriles, followed by treatment with (hetero)aryl electrophiles to access quaternary α-(hetero)arylnitrile products. A number of products were prepared using this method (34 examples, 27-99% yield). This method highlights the usefulness of malononitriles as precursors for alkylnitrile-containing compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce82ee5ba0950b63b791d8708f05ccd https://doi.org/10.1039/d2ob00236a Zobrazit plný text záznamu