The role of anterior prefrontal cortex in prospective memory: an exploratory FDG-PET study in early Alzheimer's disease
| Autor: | Stefano Grisanti, Marco Pagani, Matteo Pardini, Fabrizio De Carli, Matteo Bauckneht, Elisa Doglione, Paola Origone, Federico Massa, Andrea Brugnolo, Dario Arnaldi, Silvia Morbelli, Beatrice Orso, Laura Filippi, Flavio Nobili, Nicola Girtler |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Memory Episodic prospective memory Prefrontal Cortex Disease 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Fluorodeoxyglucose F18 Internal medicine Healthy control Healthy volunteers Prospective memory medicine Humans FDG-PET Cognitive impairment Prefrontal cortex Aged Retrospective Studies medicine.diagnostic_test business.industry General Neuroscience Alzheimer's disease MCI Early Diagnosis 030104 developmental biology Positron emission tomography Positron-Emission Tomography Correlation analysis Cardiology Female Neurology (clinical) Radiopharmaceuticals Geriatrics and Gerontology business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiology of aging 96 (2020): 117–127. doi:10.1016/j.neurobiolaging.2020.09.003 info:cnr-pdr/source/autori:Massa F, Grisanti S, Brugnolo A, Doglione E, Orso, Morbelli S, Bauckneht M, Origone P, Filippi L, Arnaldi D, De Carli F, Pardini M, Pagani M, Nobili F, Girtler N/titolo:The role of anterior prefrontal cortex in prospective memory: an exploratory FDG-PET study in early Alzheimer's disease/doi:10.1016%2Fj.neurobiolaging.2020.09.003/rivista:Neurobiology of aging/anno:2020/pagina_da:117/pagina_a:127/intervallo_pagine:117–127/volume:96 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2020.09.003 |
| Popis: | Introduction. Prospective memory (PM) is the ability of forming and maintaining an intention in memory over time while performing another task. From previous studies in healthy volunteers the prefrontal regions are deeply involved in PM, although little is known in early Alzheimer's disease (AD). Hence, we investigated the functional neural basis of PM in patients with mild cognitive impairment due to AD (MCI-AD) by assessing brain metabolism (18F-FDG PET). Methods. Eighteen patients (10 males, age:74±4.9; MMSE score:27.7±1.6) with intermediate or high likelihood of MCI-AD and a control group (HC) of 23 healthy subjects (11 males, age:71.5±5.7) underwent FDG-PET, neuropsychological evaluation and the PM-specific Shum and Ungvari paradigm test. Brain metabolism was correlated with the PM score in the two groups separately to find those brain areas correlated with PM performance ('PM cluster'), which were then used as central hub for the subsequent interregional metabolic connectivity analyses (IRCA). Results. In MCI-AD patients PM score positively correlated with metabolic levels in the right anterior prefrontal cortex (aPFC, middle and inferior frontal gyri); no correlation was found in HC. The IRCA showed in MCI-AD patients a loss of the interhemispheric connectivity of the PM cluster. Conclusion. The functioning of the right aPFC and its metabolic interhemispheric connectivity is crucial in early AD to sustain PM performance which deteriorates along with progressive metabolic failure in these regions. |
| Databáze: | OpenAIRE |
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