The Expression of CD74-Regulated Inflammatory Markers in Stage IV Melanoma: Risk of CNS Metastasis and Patient Survival
Autor: | Jason Roszik, Dai Ogata, Keiji Tanese, Roland L. Bassett, Sun-Hee Kim, Lauren E. Haydu, Junna Oba, Suhendan Ekmekcioglu, Elizabeth A. Grimm |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Cancer Research CD74 medicine.medical_treatment lcsh:RC254-282 Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stage IV medicine melanoma Receptor Tissue microarray nitrotyrosine biology business.industry Nitrotyrosine Melanoma medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology Oncology chemistry CNS metastasis 030220 oncology & carcinogenesis Cancer research biology.protein Macrophage migration inhibitory factor Cyclooxygenase prognosis business Prostaglandin E |
Zdroj: | Cancers, Vol 12, Iss 3754, p 3754 (2020) Cancers Volume 12 Issue 12 |
ISSN: | 2072-6694 |
Popis: | Innate inflammatory features have been found in melanoma tumors from patients at all stages, and molecular analysis has identified definitive inflammatory proteins expressed by tumors cells in patients who presents the worst prognosis. We have previously observed weakened outcomes in patients with constitutive expression of inducible nitric oxide synthase (iNOS), macrophage migration inhibitory factor (MIF) and improved outcomes with CD74 expression in stage III melanoma. In our current study, we tested our hypothesis on CD74-regulated inflammatory markers&rsquo expression in stage IV melanoma tumors whether the signature is associated with survival outcome and/or risk of developing CNS metastasis. We retrospectively identified 315 patients with stage IV melanoma. In a tissue microarray (TMA), we examined the expression of cells with CD74, its receptor MIF, and downstream inflammatory markers iNOS, nitrotyrosine (NT), cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1 (mPGES1). We analyzed the association of those inflammatory markers with overall survival time (OS) and time to CNS metastasis using Kaplan&ndash Meier survival analyses. Our data validates CD74 as a useful prognostic tumor cell protein marker associated with favorable OS as in stage III melanomas, while the tumor NT expression strongly predicts an increased risk of developing CNS metastasis (p = 0.0008) in those patients. |
Databáze: | OpenAIRE |
Externí odkaz: |