Neo-intimal development on textured biomaterial surfaces during clinical use of an implantable left ventricular assist device
| Autor: | K. Dasse, A Coumbe, Ct Lewis, Vehid Salih, Tr Graham, M. T. Marrinan, O. H. Frazier |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Heart Ventricles medicine.medical_treatment Polyurethanes Biocompatible Materials Fibrin Materials Testing Cell density medicine Humans Thrombus Titanium biology business.industry Biomaterial General Medicine Middle Aged medicine.disease Diaphragm (structural system) Surgery Transplantation Evaluation Studies as Topic Ventricular assist device Microscopy Electron Scanning biology.protein Heart-Assist Devices Cardiology and Cardiovascular Medicine business Calcification |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 4:182-190 |
| ISSN: | 1010-7940 |
| DOI: | 10.1016/1010-7940(90)90002-h |
| Popis: | Implantable left ventricular assist systems are being developed for long term clinical use. Prototype devices are currently used as extended mechanical bridges to cardiac transplantation. The Thermo Cardiosystems Inc. (TCI) pneumatic pusher plate left ventricular assist device (LVAD) features textured blood contacting surfaces to encourage the formation of an adherent fibrin-cellular coagulum. This serves as the foundation for the development of a neo-intimal lining. The TCI LVAD was implanted in 6 male patients (age range 22-53 years) between 1986 and 1988. The duration of implantation ranged from 1-41 days. No clinical thromboembolic events or pump-related thromboembolism occurred and none was evident at necropsy. The six device linings have been fully evaluated. Explanted devices were free of thrombus and calcification. Lining samples for light and electron microscopy were collected from areas of the diaphragm identical for flex and blood shear conditions and from high and low shear areas on the static housing. Islands of collagenous tissue were deposited on the static housing amongst compact fibrin. By day 13, cells populated the surface of the developing neo-intima overlying the diaphragm. By 41 days, the surface cell density increased and the cells became spindle shaped and relatively orientated in the high shear/flex area. Immunohistochemical techniques suggest that these cells are of mesenchymal origin. Textured blood contacting surfaces appear satisfactory in the preliminary clinical use of this device. |
| Databáze: | OpenAIRE |
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