Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum

Autor:	Ashley A. Thurstin, Allison N. Egeli, Edie C. Goldsmith, Francis G. Spinale, Holly A. LaVoie
Rok vydání:	2022
Předmět:	Mice Knockout Mice Ventricular Remodeling Physiology Pregnancy Physiology (medical) Postpartum Period Humans Animals Female Heart Cardiology and Cardiovascular Medicine
Zdroj:	American journal of physiology. Heart and circulatory physiology. 324(1)
ISSN:	1522-1539
Popis:	Pregnancy and lactation increase volume load on the heart. Defects in cardiac remodeling during pregnancy and postpartum can result in peripartum cardiomyopathy. TIMPs participate in cardiac remodeling. The present study reports the cardiac function in Timp4 knockout adult female mice during pregnancy and lactation. Timp4 knockout females at many time points have higher ejection fraction to maintain stroke volume. Global deletion of Timp4 was not detrimental to maternal heart function during first pregnancies and lactation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce345e528c590829e4d9e72b6d4baf4 https://pubmed.ncbi.nlm.nih.gov/36459450 Zobrazit plný text záznamu