Value of diffusion-weighted magnetic resonance imaging in predicting World Health Organization grade in G1/G2 pancreatic neuroendocrine tumors
| Autor: | Qidong Wang, Wenbo Xiao, Chuangen Guo, Zhongqiu Wang, Xiaoling Zhuge, Xiao Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Proliferation index diffusion-weighted imaging Neuroendocrine tumors Biology pancreatic neuroendocrine tumor 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Grading (tumors) apparent diffusion coefficients grade medicine.diagnostic_test Receiver operating characteristic business.industry Magnetic resonance imaging Articles medicine.disease Primary tumor Hyperintensity body regions Oncology 030220 oncology & carcinogenesis Nuclear medicine business Diffusion MRI |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2017.6029 |
| Popis: | The present study aimed to investigate the value of diffusion-weighted magnetic resonance imaging (DWI) in the grading of well-differentiated pancreatic neuroendocrine tumors (PanNETs). A total of 44 patients with histologically proven well-differentiated PanNET [grade 1 (G1) and grade 2 (G2) according to the World Health Organization (WHO) criteria] underwent pretreatment magnetic resonance imaging (MRI), which was retrospectively analyzed. The location, size, cystic or solid appearance, boundary, presence or absence of tumor contrast enhancement, and MRI signal of the tumor were assessed. Apparent diffusion coefficients (ADCs) within the primary tumor were measured on ADC maps. Receiver operating characteristic curves were used to determine ADC cut-off values and the sensitivity and specificity of the grade prediction. Spearman's rank correlation was utilized to probe the association between ADC value and PanNET grade or pathological parameters. G1 tumors exhibited a well-circumscribed border more often than G2 tumors. No marked differences were observed between PanNET G1 and PanNET G2 for cystic or solid appearance, enhancement, and T1- and T2-weighted imaging signals. Marked hyperintensities were more common in PanNET G2 tumors than in PanNET G1 tumors (P |
| Databáze: | OpenAIRE |
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