Apolipoprotein E type ϵ4 allele frequency is increased in patients with schizophrenia
| Autor: | Claude Michel Wischik, John H. Xuereb, McKenna Pj, Martin Roth, Charles R. Harrington |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Apolipoprotein E medicine.medical_specialty Genotype Apolipoprotein E4 Cortical Lewy body Apolipoproteins E Gene Frequency Internal medicine mental disorders medicine Humans Dementia Allele Allele frequency Alleles Aged Aged 80 and over Genetics Lewy body General Neuroscience Brain Middle Aged medicine.disease Endocrinology Schizophrenia Female Alzheimer's disease Psychology |
| Zdroj: | Neuroscience Letters. 202:101-104 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(95)12218-4 |
| Popis: | Apolipoprotein E type epsilon 4 alleles are increased in both Alzheimer's disease (AD) and cortical Lewy body dementia, while the epsilon 2 allele has been associated as a protective factor against the development of dementia in AD. We have determined APOE genotype in schizophrenic patients coming to autopsy (age range 19-95 years). The allele frequencies in this group were: epsilon 2, 6.0%; epsilon 3, 67.9%; and epsilon 4, 26.2%. Three patients (14%) were homozygous for the epsilon 4 allele. Thus, schizophrenia is associated with an increased epsilon 4 allele frequency, as compared with controls (P = 0.01), that was indistinguishable from that found in either AD or Lewy body dementia. The increased epsilon 4 allele frequency was not associated with increased age of schizophrenia patient, indicating that it was not due to the co-existence of AD. |
| Databáze: | OpenAIRE |
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