Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis
| Autor: | Yu-Ying Xu, Shao-Hua Yan, Yun Xu, Na Zhao, Yue Chen, Yunzi Yan, Bin He, Lingyun Sun, Bing Pang, Mo Tang, Shuo Feng, Yufei Yang, Ming-Kun Yu, Wen-Jia Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Neutropenia Colorectal cancer medicine.medical_treatment Herbal Medicine colorectal cancer chemotherapy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine RC254-282 Chemotherapy Leukopenia business.industry leukopenia Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Fatigue Treatment Side Effects and Rehabilitation Complementary and alternative medicine 030220 oncology & carcinogenesis Meta-analysis Chinese herbal medicine medicine.symptom business Colorectal Neoplasms Drugs Chinese Herbal Phytotherapy Research Article |
| Zdroj: | Integrative Cancer Therapies, Vol 20 (2021) Integrative Cancer Therapies |
| ISSN: | 1534-7354 |
| Popis: | Objective: To evaluate the effectiveness of Chinese Herbal Medicine (CHM) on leukopenia/neutropenia induced by chemotherapy in adults with colorectal cancer (CRC). Methods: Eight electronic databases were searched from their inception to June 2020. Randomized controlled trials with clarified sequence generation were qualified. Two reviewers independently conducted the screening and data extraction. Methodological quality was assessed using the Risk of Bias tool. RevMan 5.4 was applied to the meta-analysis. Results: Twenty-seven studies involving 1867 participants were qualified, of which 26 were included in the quantitative synthesis. Meta-analysis showed that CHM significantly reduced the incidence of leukopenia induced by chemotherapy (RR = 0.69; 95% CI 0.59-0.82), as well as the grade 3/4 leukopenia (RR = 0.71; 95% CI 0.55-0.90). Meanwhile,CHM decreased the occurrence of neutropenia (RR = 0.52, 95% CI 0.35-0.77), especially for the grades 3/4 neutropenia (RR = 0.42, 95% CI 0.27-0.64). Twenty-six of the included studies focused on the adverse events related to CHM. Conclusion: CHM may relieve neutropenia/leukopenia induced by chemotherapy in adults with colorectal cancer. |
| Databáze: | OpenAIRE |
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