Influence of sex and female hormones on nicotine-induced changes in locomotor activity in rats
| Autor: | Sakire Pogun, I.P. Stolerman, T. Saigusa, L. Kanýt, Chris Chandler |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Chronic exposure
Male medicine.medical_specialty Nicotine medicine.drug_class NICOTINE EXPOSURE Ovariectomy Clinical Biochemistry Biology Motor Activity Toxicology Biochemistry Locomotor activity Behavioral Neuroscience Sex Factors Internal medicine medicine Animals Gonadal Steroid Hormones Biological Psychiatry Progesterone Pharmacology Estradiol Biological activity Rats Endocrinology Estrogen Ovariectomized rat Female Hormone medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 62(1) |
| ISSN: | 0091-3057 |
| Popis: | KANÝT, L., I. P. STOLERMAN, C. J. CHANDLER, T. SAIGUSA AND S. POĞUN. Influence of sex and female hormones on nicotine-induced changes in locomotor activity in rats. PHARMACOL BIOCHEM BEHAV 62 (1) 179–187 1999.—The acute and chronic effects of nicotine (0.4 mg/kg SC) on locomotor activity in photocell cages have been compared in male, female, and ovariectomized hooded rats. In Experiment 1, female rats displayed higher locomotion than males ( n = 12); acutely, nicotine-reduced locomotion, and this effect was slightly larger in females than males. Daily administration of nicotine for 21 days produced a similar, gradual increase in activity in both sexes. Tests then confirmed greater activity in females than males and as a function of previous chronic exposure to nicotine ( n = 6); there was an activating effect of nicotine challenge but no interaction of nicotine effects with sex. In Experiment 2, ovariectomized rats were primed with 17-β-estradiol (50 μg/kg SC) and progesterone (2.5 mg/kg SC) or vehicle only. Acute administration of nicotine reduced activity in both groups similarly ( n = 12). After nicotine daily for 21 days, there was increased activity as a function of both chronic nicotine and hormonal priming, and challenge with nicotine increased activity ( n = 6). The effects of these challenges with nicotine were also slightly greater, as a function of previous nicotine exposure and priming. As a whole, these experiments showed robust effects of acute and chronic nicotine administration, sex, and hormonal priming; neither sex nor gonadal hormones had marked influences on changes in locomotor activity produced by nicotine. |
| Databáze: | OpenAIRE |
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