Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

Autor: Navin Maswood, Peter R. Mouton, Edward M. Tilmont, Zhiming Zhang, George S. Roth, Don M. Gash, Donald K. Ingram, Greg A. Gerhardt, Mark P. Mattson, Jennifer E. Young, Julie A. Mattison, Christopher Quigley, Robert M. Cohen, Richard Grondin, Richard E. Carson, Mark A. Lane
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Male
medicine.medical_specialty
Time Factors
Hunger
Dopamine
Neurotoxins
Caudate nucleus
Enzyme-Linked Immunosorbent Assay
Substantia nigra
Fats
Neurochemical
Neurotrophin 3
Neurotrophic factors
Internal medicine
Glial cell line-derived neurotrophic factor
Medicine
Animals
Glial Cell Line-Derived Neurotrophic Factor
Nerve Growth Factors
Caloric Restriction
Brain-derived neurotrophic factor
Neurons
Multidisciplinary
Behavior
Animal
biology
business.industry
Brain-Derived Neurotrophic Factor
Brain
Neurochemistry
Parkinson Disease
Haplorhini
Biological Sciences
Macaca mulatta
Corpus Striatum
Rats
Substantia Nigra
Disease Models
Animal
Endocrinology
Nerve growth factor
nervous system
1-Methyl-4-phenyl-1
2
3
6-tetrahydropyridine
Positron-Emission Tomography
Commentary
biology.protein
Neurotoxicity Syndromes
business
Neuroglia
medicine.drug
Popis: We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6 months on a reduced-calorie diet [30% caloric restriction (CR)] or an ad libitum control diet after which they were subjected to treatment with a neurotoxin to produce a hemiparkinson condition. After neurotoxin treatment, CR monkeys exhibited significantly higher levels of locomotor activity compared with control monkeys as well as higher levels of dopamine (DA) and DA metabolites in the striatal region. Increased survival of DA neurons in the substantia nigra and improved manual dexterity were noted but did not reach statistical significance. Levels of glial cell line-derived neurotrophic factor, which is known to promote the survival of DA neurons, were increased significantly in the caudate nucleus of CR monkeys, suggesting a role for glial cell line-derived neurotrophic factor in the anti-Parkinson's disease effect of the low-calorie diet.
Databáze: OpenAIRE
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