Mother-to-child HIV-2 transmission: comparison with HIV-1 and evaluation of factors influencing the rate of transmission. A systematic review
| Autor: | Mette Holm, Emelie ter Schiphorst, Kamille Carstens Hansen, Bo Langhoff Hønge |
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| Rok vydání: | 2021 |
| Předmět: |
Mother to child transmission
Anti-HIV Agents Human immunodeficiency virus (HIV) Mothers HIV Infections medicine.disease_cause law.invention systematic review Pregnancy law HIV Seropositivity medicine Humans Pregnancy Complications Infectious Perinatal mortality business.industry mother-to-child transmission Public Health Environmental and Occupational Health virus diseases General Medicine mortality Infectious Disease Transmission Vertical viral load Infectious Diseases Transmission (mechanics) HIV-2 HIV-1 Population study Female Parasitology Observational study business Viral load Demography Publication types |
| Zdroj: | Ter Schiphorst, E, Hansen, K C, Holm, M & Hønge, B L 2022, ' Mother-to-child HIV-2 transmission : comparison with HIV-1 and evaluation of factors influencing the rate of transmission. A systematic review ', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 116, no. 5, pp. 399-408 . https://doi.org/10.1093/trstmh/trab165 |
| ISSN: | 1878-3503 0035-9203 |
| DOI: | 10.1093/trstmh/trab165 |
| Popis: | A review and collection of data on HIV-2 mother-to-child transmission (MTCT) is absent in the literature. This systematic review and meta-analysis aims to provide a pooled estimate of the rate of HIV-2 MTCT and to identify factors influencing the rate of transmission. PubMed and EMBASE were used to identify eligible publications using a sensitive search strategy. All publications until February 2021 were considered; 146 full-text articles were assessed. Observational studies describing the rate of HIV-2 MTCT in a defined HIV-2 infected study population were included. Other publication types and studies describing HIV-1 or dually infected populations were excluded. Nine studies consisting of 901 mother-child pairs in West Africa, France and Portugal were included in the meta-analysis. The pooled rate estimate of HIV-2 MTCT for antiretroviral therapy-naïve women was 0.2% (95% CI 0.03 to 1.47%), considerably lower than that for HIV-1. The levels of maternal HIV RNA and CD4 cell count were positively related to the vertical transmission rate. Maternal HIV-2 infection did not significantly affect perinatal mortality. It was concluded that the vertical transmission of HIV-2 is lower than that of HIV-1. Maternal viral load and CD4 cell count appear to influence the rate of HIV-2 MTCT. |
| Databáze: | OpenAIRE |
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