VZV skin-test reaction, but not antibody, is an important predictive factor for postherpetic neuralgia
| Autor: | Yukiko Takao, Hideo Asada, Hiroyasu Iso, Koichi Yamanishi, Toyokazu Ishikawa, Yoshiyuki Miyazaki, Fumitake Onishi, Kyoko Imoto, Aiko Okazaki, Yasuyuki Gomi, Masayuki Okeda, Shuichiro Yano, Yasuko Mori, Yoshinobu Okuno |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Herpesvirus 3 Human viruses Population Neuralgia Postherpetic Dermatology urologic and male genital diseases Antibodies Viral Herpes Zoster Severity of Illness Index Biochemistry Japan Predictive Value of Tests Severity of illness medicine Humans Prospective Studies Prospective cohort study education Molecular Biology Aged Pain Measurement Skin Tests Aged 80 and over education.field_of_study Immunity Cellular integumentary system business.industry Postherpetic neuralgia Incidence (epidemiology) Incidence Antibody titer Lumbosacral Region virus diseases biochemical phenomena metabolism and nutrition Middle Aged medicine.disease Rash Immunity Humoral Immunology Sensation Disorders Neuralgia Female medicine.symptom business Facial Dermatoses Follow-Up Studies |
| Zdroj: | Journal of Dermatological Science. 84:e119 |
| ISSN: | 0923-1811 |
| Popis: | Background The decline of cell-mediated immunity (CMI) is thought to be related to the risk of postherpetic neuralgia (PHN) as well as herpes zoster (HZ). However, the relationship between immunological condition and the incidence of PHN is still unclear. Objective We conducted a large-scale prospective cohort study to clarify the relationship between immunological factors for varicella-zoster virus (VZV) and the incidence of PHN. Methods We carried out a cohort study on VZV immunity in a population living on an island cluster, Shozu County in Japan, and examined the people who developed HZ during a follow-up period of 3 years, with a focus on the relationship between cell-mediated and humoral immunity and the incidence of PHN. A total of 12,522 people over the age of 50 were enrolled in this study, and 401 registrants were diagnosed with HZ, including 79 PHN cases. We evaluated anatomical location and severity of skin lesion, acute pain severity, presence or absence of abnormal sensations, CMI assessed by VZV skin test, and VZV-specific antibody titer measured by serological tests. Results The incidence of PHN was significantly associated with a weak response to the VZV skin test, as well as facial or lumbosacral localization of skin rash, severe skin lesion, severe acute pain, and presence of abnormal sensations, but not related to VZV-specific antibody titer. Conclusion The incidence of PHN is significantly associated with the decline of VZV-specific CMI, but not related to VZV-specific humoral immunity. |
| Databáze: | OpenAIRE |
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