Clinical Outcomes of Frozen-Thawed Embryos Generated From Growth Hormone Stimulation in Expected Poor Responders
| Autor: | Jinliang Zhu, Ying Wang, Lixue Chen, Ping Liu, Rong Li, Jie Qiao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Zygote Endocrinology Diabetes and Metabolism Poor responder Stimulation lcsh:Diseases of the endocrine glands. Clinical endocrinology live birth Miscarriage Andrology utilization rate 03 medical and health sciences 0302 clinical medicine Endocrinology frozen-thawed cycle Ovulation Induction Pregnancy medicine Adjuvant therapy Humans Embryo Implantation Birth Rate Original Research Retrospective Studies Cryopreservation 030219 obstetrics & reproductive medicine lcsh:RC648-665 business.industry Human Growth Hormone Blastocyst Transfer Embryo medicine.disease Oocyte Embryo Transfer poor responder clinical pregnancy rate Abortion Spontaneous 030104 developmental biology medicine.anatomical_structure Treatment Outcome growth hormone Oocytes Female business Live birth Maternal Age |
| Zdroj: | Frontiers in Endocrinology, Vol 11 (2021) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | ObjectiveThis study aimed to elucidate whether growth hormone (GH) adjuvant therapy significantly improves clinical outcomes for expected poor responders in frozen-thawed cycles.MethodsExpected poor responders undergoing controlled ovarian stimulation with or without GH adjuvant therapy, and subsequently underwent the first frozen-thawed transfer from January 2017 to March 2020 were retrospectively reviewed. Maternal age was matched at a 1:1 ratio between the GH and control groups. All statistical analyses were performed with the Statistical Package for the Social Sciences software.ResultsA total of 376 frozen-thawed cycles comprised the GH and control groups at a ratio of 1:1. The number of oocytes (7.13 ± 3.93 vs. 5.89 ± 3.33; p = 0.001), two pronuclei zygotes (4.66 ± 2.76 vs. 3.99 ± 2.31; p = 0.011), and day 3 available embryos (3.86 ± 2.62 vs. 3.26 ± 2.04; p = 0.014) obtained in the GH group was significantly higher than the control group in corresponding fresh cycles. The clinical pregnancy (30.3 vs. 31.0%; p = 0.883), implantation (25.3 vs. 26.2%; p = 0.829), early abortion (16.1 vs. 15.8%; p = 0.967), and live birth rates (20.6 vs. 20.8%; p=0.980) were comparable between the two groups in frozen-thawed cycles. Improvement in the clinical pregnancy (46.8 vs. 32.1%; p = 0.075), early miscarriage (10.3 vs. 20.0%; p = 0.449), and live birth rates (35.7 vs. 18.9%; p = 0.031) was found in the subgroup of poor ovarian responders (PORs) with good quality blastocyst transfer (≥4BB) following GH co-treatment.ConclusionsGH administration would increase oocyte quantity and quality, in turn, improve live birth rate in PORs. |
| Databáze: | OpenAIRE |
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