Association Between the Presence of Anti-HLA Antibodies With Acute Rejection and Chronic Allograft Nephropathy in the First Year After Kidney Transplantation
| Autor: | K.L. Pegas, R. Toresan, Francisco José Veríssimo Veronese, Adriana Reginato Ribeiro, D.M. da Silva, M.C.C. Proença, Patrícia Hartstein Salim, Luiz Fernando Job Jobim, Roberto Ceratti Manfro, Maria Isabel Albano Edelweiss |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Time Factors Urinary system Gastroenterology Nephropathy Postoperative Complications HLA Antigens Chronic allograft nephropathy Internal medicine medicine Humans Transplantation Homologous Clinical significance Kidney transplantation Autoantibodies Transplantation Kidney biology business.industry food and beverages medicine.disease Kidney Transplantation medicine.anatomical_structure Acute Disease Immunology biology.protein Surgery Antibody business Follow-Up Studies Kidney disease |
| Zdroj: | Transplantation Proceedings. 40:718-719 |
| ISSN: | 0041-1345 |
| Popis: | The clinical relevance of anti-HLA antibodies following kidney transplantation has been a recent focus of research. Patients who present anti-HLA antibodies in the posttransplantation period have shown higher incidences of acute rejection episodes (ARE) and chronic allograft nephropathy (CAN). The objective of this study was to evaluate the presence of anti-HLA antibodies during the first year after kidney transplantation and their association with the occurrence of ARE and CAN. Eighty-eight kidney transplant recipients were evaluated for the presence of IgG anti-HLA antibodies using an enzyme-linked immunosorbent assay (LAT-M and LAT-1240, One Lambda Inc, Calif, United States). Protocol kidney biopsies were performed in consenting patients. ARE and CAN were diagnosed by clinical, laboratory, and histopathological criteria. Anti-HLA antibodies were observed in 20 (22.7%) patients. At 1 year follow-up, 26.1% presented ARE and 51.2% developed CAN. Nine patients (45%) with antibodies developed ARE as opposed to 20.6% without antibodies and 64.7% developed CAN as opposed to 47.8% of those without antibodies. In the histological analysis, the anti-HLA antibodies were associated with Banff IIA ARE (P = .001) and Banff grade II CAN (P = .012). Routine posttransplantation search for antibodies may identify cases at higher risk for acute and chronic rejection, and perhaps help to tailor the immunosuppressive regimen. |
| Databáze: | OpenAIRE |
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