Effect of Octacalcium-Phosphate-Modified Micro/Nanostructured Titania Surfaces on Osteoblast Response
| Autor: | Yanmei Zhang, Lihai Zhang, Pinliang Jiang, Peifu Tang, Jianhe Liang, Changjian Lin, Lei Ren, Ran Song |
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| Rok vydání: | 2015 |
| Předmět: |
Calcium Phosphates
Materials science Biocompatibility Simulated body fluid chemistry.chemical_element Biocompatible Materials engineering.material Models Biological Osseointegration Cell Line Mice chemistry.chemical_compound Coating Apatites Cell Adhesion medicine Animals General Materials Science Octacalcium phosphate Cell Proliferation Titanium Osteoblasts Metallurgy Osteoblast Nanostructures Corrosion medicine.anatomical_structure chemistry Chemical engineering engineering Biomineralization |
| Zdroj: | ACS Applied Materials & Interfaces. 7:14384-14396 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.5b03172 |
| Popis: | Surface structures and properties of titanium implants play a vital role in successful bone replacement. To mimic the natural bone structure, some strategies have recently focused on the preparation of multiscaled morphology on medical titanium and shown some promising results; however, relatively few efforts have been made for further enhancing the biocompatibility of such a hierarchical hybrid structure without compromising the superior bioactivity of the starting micro/nano roughness. In this study, a thin ribbonlike octacalcium phosphate (OCP) coating was electrodeposited on a hierarchically structured titania surface, maintaining its micro/nanospongelike morphology. It is indicated that the micro/nanostructured surface with deposited OCP showed an improved biomineralization ability, in comparison to that without OCP modification, when immersed in simulated body fluid (SBF). Further evaluations of cellular activities demonstrated that the introduction of OCP to the micro/nano spongelike-structured surface remarkably enhanced MC3T3-E1 cell proliferation, alkaline phosphatase activity, and extracellular matrix mineralization compared to that of cells on the micro/nanospongelike titania surface during 14 days of culturing. Meanwhile, the OCP-deposited micro/nanostructured surface displayed much a smaller passive current density and lower current response to the applied potential, resulting in the improvement of corrosion resistance. All of the evaluations suggested that the modification of the OCP coating on the prepared micro/nanospongelike titania is of superior chemical stability, biomineralization, and osteoblast activities, which indicates a favorable implant microenvironment for osseointegration in vivo. |
| Databáze: | OpenAIRE |
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