Retinal Function Assessed by ERG Before and After Induction of Ocular Aspergillosis and Treatment by the Anti-fungal, Micafungin, in Rabbits
| Autor: | Robert F. Melendez, Charles S. Ballentine, William C. Lloyd, M. Pena, Y. Trigo, William E. Sponsel, Gianmarco Paris, Margaret M. Miller, Fernando Trujillo, Aaron F. Miller, Ankit H. Patel, Neeru Kumar, Laura K. Najvar, John R. Graybill, Randolph D. Glickman, Pearl Kurian, Joseph M. Harrison |
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| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Antifungal Agents genetic structures Lipoproteins Antifungal drug Biology Pharmacology Aspergillosis Peptides Cyclic Retina Aspergillus fumigatus Echinocandins Lipopeptides Endophthalmitis Amphotericin B Physiology (medical) Electroretinography medicine Animals Mycosis Voriconazole Micafungin Triazoles bacterial infections and mycoses medicine.disease biology.organism_classification eye diseases Sensory Systems Ophthalmoscopy Vitreous Body Disease Models Animal Ophthalmology Pyrimidines Rabbits sense organs Eye Infections Fungal Follow-Up Studies medicine.drug |
| Zdroj: | Documenta Ophthalmologica. 110:37-55 |
| ISSN: | 1573-2622 0012-4486 |
| DOI: | 10.1007/s10633-005-7342-0 |
| Popis: | This study was conducted to evaluate the effectiveness of a new antifungal drug, micafungin, and standard antifungal drugs against endophthalmitis induced in a rabbit by intravitreal injection of Aspergillus fumigatus, an important fungal pathogen. Effectiveness was evaluated by the preservation of b-wave amplitude at 72 h after injection of the fungus relative to the b-wave amplitude at baseline before any intravitreal injections. A 0.06 ml inoculum of 10(6) conidia of A. fumigatus was injected into the vitreous of the right eye of all rabbits; and, 12 h later, a 0.06 ml solution containing one of 3 antifungal drugs or saline was injected into the vitreous of both eyes. All three antifungal drugs produced significant b-wave preservation at 72 h in infected eyes compared to that in infected eyes receiving saline injections. There was no statistically significant difference between the effects of micafungin and amphotericin B in the right eyes with fungal endophthalmitis, and both produced significantly more preservation of b-wave amplitude than voriconazole. Amphotericin B, but neither micafungin nor voriconazole produced significant reduction of the b-wave amplitude in the left eyes. |
| Databáze: | OpenAIRE |
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