Patterns of failure after postoperative intensity-modulated radiotherapy for locally advanced and recurrent head and neck cancer
| Autor: | Makoto Tahara, Minoru Sakuraba, Naoki Nakamura, Takaki Ariji, Atsushi Motegi, Sunao Tokumaru, Mitsuhiko Kawashima, Tetsuo Akimoto, Mitsutoshi Ooishi, Sadamoto Zenda, Satoko Arahira, Ryuichi Hayashi |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Mucositis Oncology Larynx Cancer Research medicine.medical_specialty medicine.medical_treatment Dermatitis Kaplan-Meier Estimate Xerostomia Disease-Free Survival 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Positron Emission Tomography Computed Tomography Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Postoperative Period Adverse effect Aged Neoplasm Staging Retrospective Studies business.industry Head and neck cancer Cancer Radiotherapy Dosage General Medicine Middle Aged medicine.disease Combined Modality Therapy Head and neck squamous-cell carcinoma Primary tumor Surgery Radiation therapy Treatment Outcome medicine.anatomical_structure Head and Neck Neoplasms 030220 oncology & carcinogenesis Multivariate Analysis Female Radiotherapy Intensity-Modulated Neoplasm Recurrence Local business |
| Zdroj: | Japanese Journal of Clinical Oncology. 46:919-927 |
| ISSN: | 1465-3621 0368-2811 |
| Popis: | OBJECTIVE To evaluate the feasibility of postoperative intensity-modulated radiotherapy for head and neck cancer by investigating the patterns of failure after this therapy. METHODS A retrospective chart review was performed. RESULTS Between March 2006 and December 2013, 122 consecutive patients with head and neck squamous cell carcinoma were treated by surgery followed by postoperative intensity-modulated radiotherapy. In regard to the site of the primary tumor, 59 (48%) patients had cancer of the oral cavity, 31 (26%) patients had cancer of the hypopharynx, 14 (11%) patients had cancer of the oropharynx, 10 (8%) patients had cancer of the larynx and 8 (7%) patients had cancer of unknown primary. The median follow-up period of the surviving patients was 54 months (range, 25-115). Concurrent chemotherapy was administered in 76 patients (62%). The median prescribed radiation dose was 66 Gy. The 3-year overall survival, progression-free survival, distant metastasis free survival and loco-regional control rates were 59%, 48%, 52.4% and 71%, respectively. Of the 122 patients, 32 developed loco-regional recurrence as the initial recurrence, including in-field recurrence in 26 patients, marginal recurrence in five patients and out-field recurrence in seven patients. Of the five patients with marginal recurrence, four have had two or more surgeries before the intensity-modulated radiotherapy and three had oral cavity cancer. Severe adverse events were not frequent, occurring at a frequency of |
| Databáze: | OpenAIRE |
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