Virus inactivation under the photodynamic effect of phthalocyanine zinc(II) complexes
| Autor: | Lubka Doumanova, Veselin Kussovski, Ivan Angelov, Lubomira Nikolaeva-Glomb, Mimi Remichkova, Vanya Mantareva, N. Nikolova, Luchia Mukova, Angel S. Galabov |
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| Rok vydání: | 2016 |
| Předmět: |
Anions
0301 basic medicine 030103 biophysics Indoles Light viruses Static Electricity Newcastle disease virus chemistry.chemical_element Vaccinia virus Herpesvirus 1 Human Zinc Isoindoles Coxsackievirus Photochemistry medicine.disease_cause Radiation Tolerance Newcastle disease General Biochemistry Genetics and Molecular Biology Virus 03 medical and health sciences chemistry.chemical_compound Species Specificity Viral envelope Coordination Complexes Cations medicine Photosensitizing Agents biology Chemistry Adenoviruses Human Diarrhea Virus 1 Bovine Viral biology.organism_classification Virology Enterovirus B Human 030104 developmental biology Herpes simplex virus Phthalocyanine Virus Inactivation Lasers Semiconductor Vaccinia |
| Zdroj: | Zeitschrift für Naturforschung C. 72:123-128 |
| ISSN: | 1865-7125 0939-5075 |
| DOI: | 10.1515/znc-2016-0119 |
| Popis: | Various metal phthalocyanines have been studied for their capacity for photodynamic effects on viruses. Two newly synthesized water-soluble phthalocyanine Zn(II) complexes with different charges, cationic methylpyridyloxy-substituted Zn(II)- phthalocyanine (ZnPcMe) and anionic sulfophenoxy-substituted Zn(II)-phthalocyanine (ZnPcS), were used for photoinactivation of two DNA-containing enveloped viruses (herpes simplex virus type 1 and vaccinia virus), two RNA-containing enveloped viruses (bovine viral diarrhea virus and Newcastle disease virus) and two nude viruses (the enterovirus Coxsackie B1, a RNA-containing virus, and human adenovirus 5, a DNA virus). These two differently charged phthalocyanine complexes showed an identical marked virucidal effect against herpes simplex virus type 1, which was one and the same at an irradiation lasting 5 or 20 min (Δlog=3.0 and 4.0, respectively). Towards vaccinia virus this effect was lower, Δlog=1.8 under the effect of ZnPcMe and 2.0 for ZnPcS. Bovine viral diarrhea virus manifested a moderate sensitivity to ZnPcMe (Δlog=1.8) and a pronounced one to ZnPcS at 5- and 20-min irradiation (Δlog=5.8 and 5.3, respectively). The complexes were unable to inactivate Newcastle disease virus, Coxsackievirus B1 and human adenovirus type 5. |
| Databáze: | OpenAIRE |
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