Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner
| Autor: | Astrid A. Ruefli, Joseph D. Buxbaum, Aaron M. Cypess, Paul Greengard, Carolyn A. Parker |
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| Předmět: |
Immunoblotting
chemistry.chemical_element CHO Cells Calcium-Transporting ATPases Biology Calcium Transfection Models Biological Cell Line Amyloid beta-Protein Precursor Cricetinae mental disorders Amyloid precursor protein Tumor Cells Cultured Animals Humans Protein kinase C Protein Kinase C Multidisciplinary Amyloid beta-Peptides Phospholipase C Terpenes P3 peptide Glioma Receptors Muscarinic Biochemistry of Alzheimer's disease Molecular Weight Biochemistry chemistry Second messenger system biology.protein Thapsigargin Carbachol Electrophoresis Polyacrylamide Gel Amyloid precursor protein secretase Protein Processing Post-Translational Research Article Interleukin-1 |
| Zdroj: | Scopus-Elsevier |
| Popis: | Various first messengers linked to phospholipase C, including acetylcholine and interleukin 1, regulate the production both of the secreted form of the amyloid protein precursor (APP) and of amyloid beta-protein. We have now identified intracellular signals which are responsible for mediating these effects. We show that activation of phospholipase C may affect APP processing by either of two pathways, one involving an increase in protein kinase C and the other an increase in cytoplasmic calcium levels. The effects of calcium on APP processing appear to be independent of protein kinase C activation. The observed effects of calcium on APP processing may be of therapeutic utility. |
| Databáze: | OpenAIRE |
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