Negative signaling in health and disease
| Autor: | Coggeshall Km |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
B-Lymphocytes
Protein Tyrosine Phosphatase Non-Receptor Type 6 Immunology Intracellular Signaling Peptides and Proteins Receptors Antigen B-Cell food and beverages Protein Tyrosine Phosphatase Non-Receptor Type 11 Disease Immune receptor Biology Infections Lymphocyte Activation Phosphoric Monoester Hydrolases Cell biology Pathogenesis Immune system Phosphatidylinositol-3 4 5-Trisphosphate 5-Phosphatases Humans Protein Tyrosine Phosphatases Receptors Immunologic Signal transduction Receptor Cell activation Intracellular Signal Transduction |
| Zdroj: | Immunologic Research. 19:47-64 |
| ISSN: | 1559-0755 0257-277X |
| Popis: | Signal transduction induced by receptors can elicit intracellular biochemical events that either support or inhibit cell activation. Induction of the latter has been termed "negative signaling" and can be triggered by receptors on immune cells that are distinct from activating receptors while other growth-promoting receptors induce both positive and negative signaling events. Here, the biochemistry leading to cell activation or inhibition and induced by receptors on immune cells are reviewed. Furthermore, recent experimental evidence is reviewed that indicates an important contribution of negative signaling to the intracellular survival of infectious pathogens. |
| Databáze: | OpenAIRE |
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