Changes in duodenal and nephritic Ca and P absorption in hens during different egg-laying periods
| Autor: | Gaofeng Wu, Zaixiang Zhang, Jiancheng Yang, Mingxi Zhang, Jishuang San, Shuyang Bu, Jianmin Hu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Osteolysis Transporter expression Duodenum Period (gene) Absorption (skin) Kidney Calcitriol receptor Ca and P absorption 03 medical and health sciences 0302 clinical medicine CYP24A1 Internal medicine medicine Eggshell lcsh:Social sciences (General) lcsh:Science (General) Hens Multidisciplinary Chemistry Different laying stages medicine.disease 030104 developmental biology Endocrinology medicine.anatomical_structure embryonic structures lcsh:H1-99 030217 neurology & neurosurgery Research Article lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 7, Iss 1, Pp e06081-(2021) Heliyon |
| ISSN: | 2405-8440 |
| Popis: | Ca and P metabolic disorders during the egg-laying period can reduce egg production, impair eggshell quality, and even cause bone problems in hens; however, little is known regarding the capacity of duodenal and nephritic Ca and P absorption. Here, the levels of serum Ca and P metabolic indices and the expression of duodenal and renal Ca and P transporter genes were measured in hens at different egg-laying stages. The Ca, 25-(OH)-VD3, and 1,25-(OH)2-VD3 content increased during the peak (43 weeks of age) and late (72 weeks of age) egg-laying periods compared to that during the early (23 weeks of age) egg-laying period; however, there were no differences in Pi levels among the three egg-laying periods. Moreover, duodenal VDR and CaBP-D28k mRNA expression was markedly higher but NPt2b mRNA expression was markedly lower during the peak and late egg-laying periods than during the early egg-laying period. Furthermore, nephritic CaBP-D28k, PMCA1b, and FGFR1 mRNA expression was markedly higher but NPt2a and Cyp24a1 mRNA expression was markedly lower during the peak and late egg-laying periods than during the early egg-laying period. In conclusion, the present study indicated that the increased duodenal and nephritic Ca absorption during the peak and late egg-laying periods may be associated with the VD–VDR pathway, while the decreased P absorption despite relatively stable serum P levels in all three egg-laying stages may associated with osteolysis. Ca and P absorption; Transporter expression; Duodenum; Kidney; Different laying stages; Hens. |
| Databáze: | OpenAIRE |
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