Adjuvant therapy for h igh‐risk cutaneous squamous cell carcinoma: 10‐year review
| Autor: | Shlomo A. Koyfman, Sarah J. Kurley, Robert W. Cook, Jessica L. Geiger, Mary A Hall, Aaron S. Farberg, Jason G. Newman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Clinical Review medicine.medical_specialty Skin Neoplasms Cutaneous squamous cell carcinoma cutaneous squamous cell carcinoma medicine.medical_treatment Immune checkpoint inhibitors adjuvant radiation therapy Systemic therapy Targeted therapy Clinical Reviews 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Adjuvant therapy Humans Retrospective Studies Adjuvant radiotherapy business.industry Margins of Excision Immunotherapy targeted therapy Primary lesion Combined Modality Therapy adjuvant chemotherapy Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell immunotherapy business |
| Zdroj: | Head & Neck |
| ISSN: | 1097-0347 1043-3074 |
| Popis: | Standard of care for high‐risk cutaneous squamous cell carcinoma (cSCC) is surgical excision of the primary lesion with clear margins when possible, and additional resection of positive margins when feasible. Even with negative margins, certain high‐risk factors warrant consideration of adjuvant therapy. However, which patients might benefit from adjuvant therapy is unclear, and supporting evidence is conflicting and limited to mostly small retrospective cohorts. Here, we review literature from the last decade regarding adjuvant radiation therapy and systemic therapy in high‐risk cSCC, including recent and current trials and the role of immune checkpoint inhibitors. We demonstrate evidence gaps in adjuvant therapy for high‐risk cSCC and the need for prognostic tools, such as gene expression profiling, to guide patient selection. More large‐cohort clinical studies are needed for collecting high‐quality, evidence‐based data for determining which patients with high‐risk cSCC may benefit from adjuvant therapy and which therapy is most appropriate for patient management. |
| Databáze: | OpenAIRE |
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