Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide
| Autor: | Thomas E. Chused, Phillip J. Baker, Benjamin Prescott, Christopher E. Taylor, Ada Brooks, Philip W. Stashak, George Caldes |
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| Jazyk: | angličtina |
| Rok vydání: | 1983 |
| Předmět: |
Idiotype
Immunology Hemolytic Plaque Technique Lymphocyte Activation Binding Competitive T-Lymphocytes Regulatory Microbiology Feedback Epitopes Mice Immune system Cell–cell interaction Antigen medicine Immunology and Allergy Animals Antibody-Producing Cells B cell B-Lymphocytes Mice Inbred BALB C biology Polysaccharides Bacterial Immunization Passive T lymphocyte Articles Antibodies Bacterial B-1 cell medicine.anatomical_structure Immunity Active biology.protein Female Binding Sites Antibody Antibody Spleen |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | The transfer of B lymphocytes from mice immunized with type III pneumococcal polysaccharide (SSS-III) results in antigen-specific suppression of the antibody response of recipients immunized with SSS-III. Such suppression shares many features associated with low-dose paralysis, a phenomenon mediated by suppressor T cells; it reaches maximal levels 3 d after the transfer of viable or irradiated immune B cells and can be eliminated by the depletion of SSS-III-binding cells from spleen cell suspensions before transfer. In a two-step cell transfer experiment, purified T lymphocytes, isolated from recipients previously given immune B cells, caused suppression upon transfer to other mice immunized with SSS-III. Also, B-cell-induced suppression could be abrogated in a competitive manner by the infusion of amplifier T lymphocytes, as was previously demonstrated in the case of low-dose paralysis. These findings suggest that B cell surface components, presumably the idiotypic determinants of cell-associated antibody specific for SSS-III, are instrumental in activating suppressor T cells involved in regulating the magnitude of the antibody response to SSS-III. |
| Databáze: | OpenAIRE |
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