Efficacy of Ramelteon for delirium after lung cancer surgery
| Autor: | Mitsugu Omasa, Ryo Miyata, Ryo Fujimoto, Minoru Aoki, Hiroyuki Ishikawa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Lung Neoplasms Ramelteon 03 medical and health sciences Postoperative Complications 0302 clinical medicine Intensive care medicine Humans 030212 general & internal medicine Pneumonectomy Lung cancer Aged Retrospective Studies Aged 80 and over Lung cancer surgery business.industry Incidence Incidence (epidemiology) Medical record Delirium Historically Controlled Study Postoperative complication medicine.disease Checklist Indenes Anesthesia Female Surgery medicine.symptom Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Interactive CardioVascular and Thoracic Surgery. 24:8-12 |
| ISSN: | 1569-9285 1569-9293 |
| DOI: | 10.1093/icvts/ivw297 |
| Popis: | Objectives The aim of the study was to evaluate the feasibility of Ramelteon for the prevention of delirium after lung cancer surgery in elderly patients. Methods Medical records of patients over 70 years old, who underwent anatomical pulmonary resection for lung cancer at our institution from January 2013 to December 2015, were reviewed. Patients treated in 2013 and 2014 were used as a control group. Ramelteon was administered daily for 7 days after surgery. The incidence of delirium was determined based on the Intensive Care Delirium Screening Checklist (ICDSC). Scores of ≥4 and 1-3 points were used for the diagnoses of delirium and a pre-delirious state, respectively. Results There were 24 patients in the Ramelteon group and 58 patients in the control group. ICDSC scores of ≥4 points were found for no patients in the Ramelteon group and 5 (9%) in the control group, whereas 21 (88%) and 49 (85%) patients, in the respective groups, had ICDSC scores of 0 points. The average incidence of events, associated with delirium, showed a trend of being lower in the Ramelteon group (0.25 ± 0.74 vs 1.58 ± 4.93, P = 0.061), and all events in the Ramelteon group occurred on the day of surgery. Thus, only one day was required for complete recovery from delirium in the Ramelteon group, whereas 8 days were needed in the control group. The peak delirious state occurred after 5 days in the control group. Conclusions Ramelteon is likely to reduce the incidence and intensity of delirium after surgery for lung cancer in elderly patients. |
| Databáze: | OpenAIRE |
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