Drug interactions involving antiepileptic drugs: Assessment of the consistency among three drug compendia and FDA-approved labels
| Autor: | Yonatan Eyal, Matanya Tirosh, Dana Ekstein, Sara Eyal |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Drug
Drug-Related Side Effects and Adverse Reactions Databases Pharmaceutical Concordance media_common.quotation_subject Bioinformatics Treatment failure law.invention Toxicology Behavioral Neuroscience Cytochrome P-450 Enzyme System law Humans Medicine Drug Interactions Adverse effect Drug Labeling media_common Clinical pharmacology United States Food and Drug Administration business.industry Drug interaction United States Neurology Anticonvulsants Neurology (clinical) business |
| Zdroj: | Epilepsy & Behavior. 44:218-224 |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2015.02.009 |
| Popis: | Interactions of antiepileptic drugs (AEDs) with other substances may lead to adverse effects and treatment failure. To avoid such interactions, clinicians often rely on drug interaction compendia. Our objective was to compare the concordance for twenty-two AEDs among three drug interaction compendia (Micromedex, Lexi-Interact, and Clinical Pharmacology) and the US Food and Drug Administration-approved product labels. For each AED, the overall concordance among data sources regarding existence of interactions and their classification was poor, with less than twenty percent of interactions listed in all four sources. Concordance among the three drug compendia decreased with the fraction of the drug excreted unchanged and was greater for established inducers of hepatic drug-metabolizing enzymes than for the drugs that are not inducers (R-square=0.83, P0.01). For interactions classified as contraindications, major, and severe, concordance among the four data sources was, in most cases, less than 30%. Prescribers should be aware of the differences between drug interaction sources of information for both older AEDs and newer AEDs, in particular for those AEDs which are not involved in hepatic enzyme-mediated interactions. |
| Databáze: | OpenAIRE |
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